{"id":"W4281780613","doi":"10.1200/jco.2022.40.16_suppl.3082","title":"Circulating tumor DNA (ctDNA) determinants of improved outcomes in patients (pts) with advanced solid tumors receiving the ataxia telangiectasia and Rad3-related inhibitor (ATRi), RP-3500, in the phase 1/2a TRESR trial (NCT04497116).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Internal medicine; Peripheral blood mononuclear cell; Oncology; Germline; Gastroenterology; Gene; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004553663,0.0001700988,0.000304523,0.0001438434,0.0001046418,0.000310493,0.0001498427,0.0002774847,0.001732597],"category_scores_gemma":[0.0005828867,0.0001074366,0.00017807,0.0002244759,0.0001528839,0.0002214012,0.0001905574,0.0004350309,0.000255084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002315376,"about_ca_system_score_gemma":0.0002579968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004431773,"about_ca_topic_score_gemma":0.0008463854,"domain_scores_codex":[0.9998614,0.00004861543,0.00001067128,0.00004059029,0.00002005184,0.00001866554],"domain_scores_gemma":[0.9995856,0.00009293989,0.0001668473,0.00001633376,0.00002263604,0.0001156692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.08822517,0.001038942,0.8533211,0.0002204376,0.0003584523,0.000289119,0.0001154699,0.00113738,0.0160118,0.00008104817,0.002322066,0.03687897],"study_design_scores_gemma":[0.004243973,0.02924432,0.9598988,0.00003041666,0.0003661588,0.0007429737,0.00007086223,0.001787488,0.001959049,0.0001201117,0.001525791,0.00001020158],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998763,0.0002870259,0.0000742415,0.00004380925,0.000004881366,0.0000314711,0.000482168,0.000006554329,0.0003069906],"genre_scores_gemma":[0.9987009,0.00007958753,0.0001125685,0.00004901253,0.0000126222,0.00003336944,0.0007648506,0.000001652644,0.0002454467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001732597,"threshold_uncertainty_score":0.005796075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02617330851485843,"score_gpt":0.3780055847363402,"score_spread":0.3518322762214818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}