{"id":"W4281782366","doi":"10.1038/s41531-022-00330-x","title":"Quantitative detection of α-Synuclein and Tau oligomers and other aggregates by digital single particle counting","year":2022,"lang":"en","type":"article","venue":"npj Parkinson s Disease","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Bundesministerium für Bildung und Forschung; Alzheimer's Association; National Institute on Aging; Deutsche Forschungsgemeinschaft; EU Joint Programme – Neurodegenerative Disease Research; European Commission; ALS Association; Michael J. Fox Foundation for Parkinson's Research; Weston Brain Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Progressive supranuclear palsy; Dementia with Lewy bodies; Biomarker; Receiver operating characteristic; Pathology; Corticobasal degeneration; Protein aggregation; Dementia; Alpha-synuclein; Area under the curve; Chemistry; Internal medicine; Parkinson's disease; Medicine; Disease; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001227041,0.0006039393,0.0004931765,0.001933352,0.0002543261,0.0006480712,0.0005836556,0.000596326,0.0009285113],"category_scores_gemma":[0.001872436,0.0002617258,0.0002276147,0.0008531002,0.0004663492,0.0005574559,0.0004451112,0.0004190926,0.0005115847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005377026,"about_ca_system_score_gemma":0.0003131289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001129787,"about_ca_topic_score_gemma":0.001515559,"domain_scores_codex":[0.9989209,0.0001467477,0.0000799257,0.0003175145,0.0004742521,0.00006068174],"domain_scores_gemma":[0.9988967,0.0004918598,0.0001706664,0.00011612,0.0002619832,0.00006264756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002440676,0.0001030918,0.01529092,0.0001549506,0.00004463381,0.00007506675,0.0001323173,0.001121177,0.9389603,0.0004363046,0.0004123365,0.04302492],"study_design_scores_gemma":[0.00002312682,0.0004832445,0.04297429,0.00002863521,0.0000752008,0.0006107648,0.0001316072,0.06313676,0.8884327,0.0008108267,0.003231559,0.00006130947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7069392,0.003748997,0.2803882,0.0001480782,0.0001560007,0.0003120878,0.002182679,0.00157518,0.004549591],"genre_scores_gemma":[0.7552198,0.002157314,0.235413,0.0001541445,0.00006103154,0.0005197724,0.001751358,0.00009069491,0.004632999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001933352,"threshold_uncertainty_score":0.006489277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01856010162800577,"score_gpt":0.2517440345173651,"score_spread":0.2331839328893593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}