{"id":"W4281782658","doi":"10.1016/j.clinthera.2022.05.002","title":"Impact of Methotrexate Discontinuation, Interruption, or Persistence in US Patients with Rheumatoid Arthritis Initiating Tofacitinib + Oral Methotrexate Combination","year":2022,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Pfizer","keywords":"Tofacitinib; Medicine; Discontinuation; Janus kinase inhibitor; Rheumatoid arthritis; Cohort; Methotrexate; Internal medicine; Retrospective cohort study; Medical prescription; Cohort study; Surgery; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002442728,0.0002284405,0.000476771,0.001122477,0.0003523766,0.0010523,0.0003776831,0.0004513732,0.001139983],"category_scores_gemma":[0.01139401,0.0002117694,0.00117424,0.002048441,0.0003045146,0.0005429762,0.0006585735,0.0007252741,0.0001146608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008929886,"about_ca_system_score_gemma":0.0009006384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01156411,"about_ca_topic_score_gemma":0.01267083,"domain_scores_codex":[0.995817,0.001575697,0.0008615196,0.000595599,0.0008425944,0.0003075911],"domain_scores_gemma":[0.9836681,0.002574403,0.01224228,0.000438595,0.0005332942,0.0005432483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003154954,0.00003245526,0.997433,0.000023701,0.0002670249,0.00003441471,0.00003259473,0.00008798201,0.00003481474,0.00001827847,0.00008809317,0.001632186],"study_design_scores_gemma":[0.00005111701,0.0002206509,0.9978349,0.00005233106,0.0002566333,0.0003130896,0.0001496422,0.0006623071,0.00005985806,0.00003883047,0.000354279,0.000006539339],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969311,0.001193493,0.00006862197,0.0001334387,0.000007562376,0.00001262933,0.001140036,0.000003000925,0.0005100612],"genre_scores_gemma":[0.9989819,0.0001974702,0.00005289607,0.00005002887,0.00001464049,0.00001000013,0.0006550105,0.0000011444,0.00003696395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01156411,"threshold_uncertainty_score":0.02299356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1373242789101798,"score_gpt":0.4187582041071701,"score_spread":0.2814339251969904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}