{"id":"W4281782658","doi":"10.1016/j.clinthera.2022.05.002","title":"Impact of Methotrexate Discontinuation, Interruption, or Persistence in US Patients with Rheumatoid Arthritis Initiating Tofacitinib + Oral Methotrexate Combination","year":2022,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Pfizer","keywords":"Tofacitinib; Medicine; Discontinuation; Janus kinase inhibitor; Rheumatoid arthritis; Cohort; Methotrexate; Internal medicine; Retrospective cohort study; Medical prescription; Cohort study; Surgery; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001947227,0.0002298678,0.0007539868,0.0002449212,0.0001783717,0.00003919086,0.0002096754,0.00008030744,0.0007673225],"category_scores_gemma":[0.0006699299,0.0001695032,0.0002762851,0.0006498263,0.0003373676,0.000239681,0.0001240534,0.0006605964,0.000005136169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001430417,"about_ca_system_score_gemma":0.0003274229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008800397,"about_ca_topic_score_gemma":0.00009040981,"domain_scores_codex":[0.9962013,0.001153077,0.001182978,0.0003879323,0.0006759838,0.0003987637],"domain_scores_gemma":[0.9977146,0.0008191675,0.0004813162,0.0003613688,0.0004665368,0.0001570593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002789975,0.001808856,0.8463413,0.00001352704,0.0003568732,0.00001879818,0.001160713,0.00006475111,0.00008300631,0.0001125909,0.00001996311,0.1472296],"study_design_scores_gemma":[0.01487803,0.008955775,0.9706107,0.0003973183,0.00001607584,0.00003495061,0.001000765,0.00222567,0.0001008699,0.0004033383,0.001109276,0.0002672489],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971843,0.0007947558,0.0005579416,0.0002460805,0.0001242236,0.0007147312,0.0001136755,0.00004196811,0.0002223196],"genre_scores_gemma":[0.9914941,0.005593108,0.002277212,0.0002444103,0.0000149176,0.00007778114,0.0002016526,0.0000420256,0.00005482405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1469624,"threshold_uncertainty_score":0.8401643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1373242789101798,"score_gpt":0.4187582041071701,"score_spread":0.2814339251969904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}