{"id":"W4281782900","doi":"10.1016/j.xphs.2022.05.021","title":"Purification and Surface Modification of Chitosan-based Polyplexes Using Tangential Flow Filtration and Coating by Hyaluronic Acid","year":2022,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Polymer Surface Interaction Studies","field":"Materials Science","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Polytechnique Montréal","funders":"Aries Pharmaceuticals","keywords":"Hyaluronic acid; Chitosan; Coating; Filtration (mathematics); Surface modification; Cross-flow filtration; Chemistry; Size-exclusion chromatography; Chromatography; Flow (mathematics); Chemical engineering; Materials science; Biomedical engineering; Organic chemistry; Biochemistry; Membrane; Medicine; Mathematics; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002740102,0.0002694869,0.0001909928,0.000196836,0.0001769959,0.0003139703,0.0002085714,0.0002746161,0.0007631541],"category_scores_gemma":[0.0004173717,0.0001519729,0.0002488327,0.0002168831,0.0001556436,0.0002621803,0.0001926923,0.0004532948,0.0003068518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003062869,"about_ca_system_score_gemma":0.0002247146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009535241,"about_ca_topic_score_gemma":0.0008366733,"domain_scores_codex":[0.9997959,0.00002804658,0.00002560303,0.00005256789,0.00005235974,0.00004565113],"domain_scores_gemma":[0.9998347,0.00004780315,0.00003667159,0.00001758154,0.00003533672,0.00002794653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004064343,0.00001239008,0.00005244884,0.00001542584,0.000004308688,0.00001856697,0.00001665429,0.00008571208,0.9984377,0.00003822509,0.0000250565,0.001252969],"study_design_scores_gemma":[0.000003152617,0.00005381007,0.0004604156,0.000001105596,0.000004225396,0.00003181666,0.000005104281,0.0004326242,0.9984236,0.000008709379,0.0005729066,0.000002488881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826203,0.0008182674,0.01489872,0.00009428566,0.00003650182,0.00005535393,0.0001473673,0.00007934304,0.001249885],"genre_scores_gemma":[0.9836439,0.0004607553,0.01032262,0.00007634443,0.00001086688,0.00003655493,0.0005197335,0.00004764999,0.004881428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009535241,"threshold_uncertainty_score":0.002552986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0802716422101035,"score_gpt":0.3742689810817244,"score_spread":0.2939973388716208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}