{"id":"W4281783366","doi":"10.1016/j.celrep.2022.110919","title":"Stub1 maintains proteostasis of master transcription factors in embryonic stem cells","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"National Key Research and Development Program of China Stem Cell and Translational Research; National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Proteostasis; Embryonic stem cell; Cell biology; Transcription factor; Biology; Transcription (linguistics); Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004979227,0.0001433288,0.0001844527,0.000124399,0.00006763578,0.00001040782,0.000160997,0.00007958818,0.0001537538],"category_scores_gemma":[0.000005844739,0.0001455806,0.0001242973,0.0001774759,0.00004327313,0.000004259114,0.0001838777,0.0001859187,0.000002327148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007877368,"about_ca_system_score_gemma":0.0001500624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005373967,"about_ca_topic_score_gemma":0.0000278282,"domain_scores_codex":[0.9982821,0.0001762657,0.0004012682,0.0004376172,0.0003826254,0.0003201374],"domain_scores_gemma":[0.9992129,0.000007897851,0.0001852984,0.0004735258,0.00004589507,0.00007443811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006962271,0.0001840878,0.01292443,0.00008819621,0.00001504522,0.0001849923,0.0001576258,0.0007123764,0.984956,0.000001536124,0.0004061353,0.0002999375],"study_design_scores_gemma":[0.0002784307,0.0003558386,0.001934418,0.000006982685,0.000008272772,0.00003492944,0.000722569,0.00002414456,0.9792194,0.00001262369,0.01725517,0.000147222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971105,0.0003656816,0.0001259856,0.00003404608,0.0001971718,0.0006583845,0.00002554908,0.000007508804,0.001475118],"genre_scores_gemma":[0.9929476,0.00005014938,0.00004219636,0.00001958121,0.00001899799,0.00008675599,0.00008576193,0.00002789959,0.006721107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01684904,"threshold_uncertainty_score":0.5936606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02132973906034574,"score_gpt":0.2427437552573641,"score_spread":0.2214140161970183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}