{"id":"W4281789731","doi":"10.1101/2022.06.09.495548","title":"Gait Abnormalities and Aberrant D2 Receptor Expression and Signaling in a Mouse Model of the Human Pathogenic Mutation <i> DRD2 <sup>I212F</sup> </i>","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Drug Abuse; York University; Rijksuniversiteit Groningen; Oregon Health and Science University; New York University Abu Dhabi; National Institute of Neurological Disorders and Stroke; Office of Research and Development; U.S. Department of Veterans Affairs","keywords":"Dopamine receptor D2; Dopamine; Nucleus accumbens; Striatum; Sulpiride; Endocrinology; Internal medicine; Dopamine receptor; Neuroscience; Dopamine receptor D1; Biology; Medicine; Dopaminergic","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002267563,0.001085669,0.0003608996,0.0009314935,0.0003410036,0.0004166279,0.0003877108,0.001065007,0.003465126],"category_scores_gemma":[0.0001713435,0.0004052549,0.0005088024,0.000277881,0.0005729109,0.0002398144,0.0003205567,0.001214079,0.0008494143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005422416,"about_ca_system_score_gemma":0.0002497158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001437701,"about_ca_topic_score_gemma":0.001507202,"domain_scores_codex":[0.9996858,0.00005613367,0.00005140388,0.00008770619,0.00007599987,0.00004303228],"domain_scores_gemma":[0.9997754,0.00002847017,0.00009136558,0.00001700719,0.00001558076,0.00007213372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000473282,0.000281169,0.0005506882,0.00004101729,0.00002505102,0.001468257,0.00003355066,0.0001847836,0.9949791,0.0002649277,0.0002652849,0.001432966],"study_design_scores_gemma":[0.0008598385,0.005301454,0.03436963,0.0001068641,0.0002169539,0.03125638,0.0002763215,0.007743914,0.9096351,0.0005056948,0.009654333,0.0000735084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923728,0.0003902437,0.003232981,0.0003334123,0.00006630768,0.00009670481,0.0017533,0.0002359278,0.001518405],"genre_scores_gemma":[0.9881627,0.0004100048,0.004346661,0.0002419416,0.00002592039,0.0001564533,0.001569099,0.0001159147,0.004971284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003465126,"threshold_uncertainty_score":0.01159197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01208711804589922,"score_gpt":0.2103585389286234,"score_spread":0.1982714208827241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}