{"id":"W4281818131","doi":"10.1200/jco.2022.40.16_suppl.e19553","title":"Pharmacokinetics (PK) and pharmacodynamics (PD) in First-MIND: A phase Ib, open-label, randomized study of tafasitamab (tafa) ± lenalidomide (LEN) in addition to R-CHOP in patients (pts) with newly diagnosed diffuse large B-cell lymphoma (DLBCL).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"MorphoSys","keywords":"Medicine; CHOP; Neutropenia; Internal medicine; Lenalidomide; Clinical endpoint; Gastroenterology; Pharmacodynamics; Diffuse large B-cell lymphoma; Pharmacokinetics; Lymphoma; Clinical trial; Toxicity; Multiple myeloma","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00157951,0.001332807,0.002050561,0.0003435023,0.0003371224,0.001058833,0.0008941065,0.001251581,0.003599349],"category_scores_gemma":[0.001525011,0.0007804166,0.001250672,0.000383715,0.001099408,0.001115382,0.000441299,0.003500099,0.000748014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001005574,"about_ca_system_score_gemma":0.00121545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004837465,"about_ca_topic_score_gemma":0.001215227,"domain_scores_codex":[0.9994277,0.0003157555,0.0000293422,0.00009135665,0.00004893864,0.0000868061],"domain_scores_gemma":[0.9988906,0.0002126421,0.0002710298,0.00009454509,0.00004531666,0.0004858489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9248241,0.0319292,0.002643696,0.0002034478,0.0004108536,0.0000682782,0.00009244068,0.0007953211,0.01599004,0.00007233796,0.0005568935,0.02241343],"study_design_scores_gemma":[0.5789368,0.4084959,0.007355456,0.00001649227,0.0004116512,0.0001443229,0.00003916004,0.0009306485,0.002406358,0.0001436283,0.001091614,0.00002799704],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964574,0.0006116414,0.0003308837,0.0001613136,0.00007242802,0.001338296,0.0003473549,0.00004874222,0.0006318293],"genre_scores_gemma":[0.9950669,0.0004555589,0.0009621298,0.0003683816,0.0001621335,0.00142575,0.000517388,0.00001436461,0.00102733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003599349,"threshold_uncertainty_score":0.01204103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05469298407522082,"score_gpt":0.422782853376907,"score_spread":0.3680898693016861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}