{"id":"W4281829220","doi":"10.1093/neuonc/noac079.301","title":"IMMU-08. Nivolumab with or without ipilimumab in pediatric patients with high-grade CNS malignancies: efficacy, safety, biomarker, and pharmacokinetic results from Checkmate 908","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Nivolumab; Ipilimumab; Internal medicine; Oncology; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003573737,0.0004245378,0.000830358,0.0003852439,0.0002412426,0.0000233686,0.0002671141,0.0001383948,0.0003464646],"category_scores_gemma":[0.00007193552,0.0003104377,0.00007273186,0.001035365,0.0002924059,0.00009932495,0.000220695,0.0005982983,0.00000881997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000556895,"about_ca_system_score_gemma":0.0006960562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009579636,"about_ca_topic_score_gemma":0.0004955214,"domain_scores_codex":[0.9966987,0.0004187584,0.000765333,0.0009171478,0.000571376,0.0006286573],"domain_scores_gemma":[0.998199,0.0005867134,0.000433783,0.000502239,0.00008394596,0.000194306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.598469,0.004771798,0.2322497,0.0001968083,0.0005913442,0.002096188,0.003874646,0.0001160424,0.09850366,0.000004355343,0.006883099,0.05224336],"study_design_scores_gemma":[0.1885343,0.01820269,0.7171934,0.00009556464,0.0006756726,0.0003409809,0.0005233,0.0002965884,0.002417786,0.000007115446,0.0710106,0.0007020768],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942411,0.0006646889,0.000007034757,0.002023953,0.0005672064,0.001607284,0.0003871864,0.0001125942,0.0003889114],"genre_scores_gemma":[0.9958575,0.001130273,0.0004302714,0.001697099,0.0001465398,0.0001751886,0.0003044022,0.00009321297,0.0001655494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4849437,"threshold_uncertainty_score":0.9999348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01715287258485537,"score_gpt":0.2739093106069385,"score_spread":0.2567564380220831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}