{"id":"W4281829220","doi":"10.1093/neuonc/noac079.301","title":"IMMU-08. Nivolumab with or without ipilimumab in pediatric patients with high-grade CNS malignancies: efficacy, safety, biomarker, and pharmacokinetic results from Checkmate 908","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Medicine; Nivolumab; Ipilimumab; Internal medicine; Oncology; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008125775,0.0003062416,0.0005581782,0.0002206453,0.000140477,0.0006626662,0.0004490943,0.000336877,0.001987203],"category_scores_gemma":[0.0006752383,0.0001660231,0.0005617772,0.0002607487,0.0002822816,0.0003860191,0.0002303665,0.001038786,0.0003773115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00100401,"about_ca_system_score_gemma":0.0009722683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001104734,"about_ca_topic_score_gemma":0.002825133,"domain_scores_codex":[0.9997432,0.00009457707,0.00001734293,0.00005897139,0.00005144411,0.00003442856],"domain_scores_gemma":[0.999545,0.00008147395,0.0001511302,0.00003957231,0.00003678523,0.0001459292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.310374,0.01367016,0.1403121,0.001747842,0.002065913,0.0004287331,0.0003059756,0.006199719,0.1034504,0.0006192248,0.009874355,0.4109517],"study_design_scores_gemma":[0.1084891,0.4404615,0.3430539,0.0003079133,0.00294707,0.002570694,0.0001999568,0.01140921,0.06469782,0.0003644625,0.02541178,0.00008657601],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937809,0.003381174,0.0002355317,0.0001541425,0.00002700203,0.0001366926,0.0008767659,0.00006191421,0.001345973],"genre_scores_gemma":[0.9960061,0.0008247794,0.0006524607,0.0002237524,0.00002714981,0.0001015666,0.001588205,0.00001125253,0.0005647608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001987203,"threshold_uncertainty_score":0.007284641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01715287258485537,"score_gpt":0.2739093106069385,"score_spread":0.2567564380220831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}