{"id":"W4281832698","doi":"10.1016/j.cell.2022.05.008","title":"The Parkinson’s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability","year":2022,"lang":"en","type":"article","venue":"Cell","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":168,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Canada Research Chairs","funders":"National Institute of General Medical Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health","keywords":"Alpha-synuclein; Biology; Cell biology; Cytosol; Organelle; Messenger RNA; Scaffold protein; Neurodegeneration; Translation (biology); Plasma protein binding; Parkinson's disease; Transport protein; Function (biology); Biochemistry; Gene; Disease; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001757705,0.000128199,0.0001839644,0.0000299126,0.0003812396,0.00002066667,0.0000772897,0.00001691921,0.0001758224],"category_scores_gemma":[0.00002792618,0.00009015092,0.00007501458,0.00006085917,0.00008858237,0.00004488945,0.0001267099,0.00009628241,0.000003241583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007306243,"about_ca_system_score_gemma":0.000160583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002834342,"about_ca_topic_score_gemma":0.000002927402,"domain_scores_codex":[0.9989699,0.00006053209,0.000177004,0.0002855404,0.0003099132,0.000197159],"domain_scores_gemma":[0.9993231,0.00002086333,0.0001026838,0.0003060454,0.00004767737,0.0001996264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01284962,0.01349378,0.541343,0.007650916,0.0009276392,0.001092449,0.01674176,0.00002668176,0.2462395,0.0006533706,0.005189698,0.1537917],"study_design_scores_gemma":[0.007862231,0.001228553,0.3999441,0.000220477,0.0009513412,0.000016085,0.003069032,0.007607838,0.2307483,0.006610252,0.3411199,0.0006218617],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992162,0.005880237,0.00001186545,0.0006023248,0.00003618203,0.0007108974,0.0001119538,0.00002936853,0.0004551642],"genre_scores_gemma":[0.9984962,0.00005117095,0.0001925452,0.0001311534,0.0000206557,0.000266534,0.000009109208,0.00001900654,0.0008136597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3359302,"threshold_uncertainty_score":0.3676248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01792342380820778,"score_gpt":0.2398191101659319,"score_spread":0.2218956863577241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}