{"id":"W4281844964","doi":"10.1093/nar/gkac483","title":"ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia","year":2022,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute; Centre Hospitalier de l’Université de Montréal","funders":"Genome Canada; Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Arthritis Society; Génome Québec; Natural Sciences and Engineering Research Council of Canada; Fondation Jean-Louis Lévesque","keywords":"Biology; Ubiquitin ligase; Germline; Transcription (linguistics); Ubiquitin; Gene; Cancer research; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001046837,0.0005127246,0.00018925,0.0005276225,0.000293543,0.0003036744,0.0001735464,0.0004186548,0.001274477],"category_scores_gemma":[0.0001196209,0.0001077743,0.0002719953,0.0002664713,0.0002134894,0.000109408,0.0002334059,0.0002533544,0.0002738512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005295847,"about_ca_system_score_gemma":0.0002062257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001588064,"about_ca_topic_score_gemma":0.00149652,"domain_scores_codex":[0.999891,0.00001037792,0.0000107243,0.0000381128,0.00003130218,0.00001838831],"domain_scores_gemma":[0.9999219,0.000006567225,0.00003008328,0.000007016335,0.000009468472,0.00002498155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002714435,0.0000173605,0.007855782,0.0001879166,0.00006473342,0.001640814,0.00002748123,0.000451532,0.9805539,0.0003916074,0.0002465895,0.008290796],"study_design_scores_gemma":[0.00002719431,0.0001804185,0.1354419,0.00006440962,0.0002013487,0.008590866,0.00007458192,0.003844786,0.8308576,0.0004514849,0.02023748,0.00002801998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800962,0.009341864,0.006179655,0.0001677413,0.00005497961,0.00002543389,0.001690761,0.0002119965,0.002231199],"genre_scores_gemma":[0.9952571,0.0006237916,0.001523851,0.00006009679,0.000006859679,0.000007166102,0.001068891,0.000009233296,0.001443108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001588064,"threshold_uncertainty_score":0.00426352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05322687414500211,"score_gpt":0.3322191941266808,"score_spread":0.2789923199816787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}