{"id":"W4281849334","doi":"10.1200/jco.2022.40.16_suppl.3551","title":"Impact of consensus molecular subtyping (CMS) on survival in the CO.26 trial of durvalumab plus tremelimumab versus best supportive care (BSC) in metastatic colorectal cancer (mCRC).","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; Ottawa Hospital; University of British Columbia; Queen's University; University of Ottawa; Genome British Columbia","funders":"","keywords":"Tremelimumab; Medicine; Durvalumab; Internal medicine; Colorectal cancer; Hazard ratio; Subtyping; Oncology; Surgical oncology; Population; Bevacizumab; Refractory (planetary science); Gastroenterology; Confidence interval; Cancer; Immunotherapy; Chemotherapy; Nivolumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003068668,0.0005255272,0.000903702,0.000248684,0.0001730441,0.0005296576,0.0003252113,0.0005693622,0.001257023],"category_scores_gemma":[0.002964461,0.0001645618,0.0008860236,0.0002120294,0.0003016836,0.0003325542,0.0003274541,0.001044787,0.0001861872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007247049,"about_ca_system_score_gemma":0.0006409147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005304726,"about_ca_topic_score_gemma":0.001935517,"domain_scores_codex":[0.9989944,0.0006420451,0.00003966304,0.0001487217,0.00008424433,0.00009100536],"domain_scores_gemma":[0.9977991,0.001020951,0.0006188397,0.0001052664,0.00009255295,0.0003632254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8382374,0.001423435,0.06351478,0.0005820718,0.002817275,0.00006492349,0.00009149273,0.002821917,0.01146916,0.0002052447,0.002356224,0.07641599],"study_design_scores_gemma":[0.2783691,0.242162,0.4328364,0.0002856878,0.008655367,0.0006775599,0.0001563915,0.01890895,0.01118395,0.001044317,0.005593253,0.0001269826],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963911,0.002057285,0.0001889358,0.0002607435,0.0000464517,0.000117282,0.0002972184,0.00001696589,0.0006239398],"genre_scores_gemma":[0.9981039,0.0003246906,0.0003165536,0.0001890064,0.00005446733,0.0001040964,0.0005787703,0.000005179563,0.0003233103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003068668,"threshold_uncertainty_score":0.01622885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1856806100505298,"score_gpt":0.5178358373433549,"score_spread":0.3321552272928252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}