{"id":"W4281851321","doi":"10.1111/jnc.15650","title":"Investigating the <scp>NLRP3</scp> inflammasome and its regulator <scp>miR</scp>‐223‐3p in multiple sclerosis and experimental demyelination","year":2022,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research; Multiple Sclerosis Society of Canada","keywords":"Inflammasome; Microglia; Myelin; Multiple sclerosis; Pyrin domain; Neuroinflammation; Inflammation; Innate immune system; Immunology; Regulator; Downregulation and upregulation; Cell biology; Immune system; Chemistry; Medicine; Cancer research; Biology; Central nervous system; Neuroscience; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001742556,0.0002817556,0.0002944907,0.0001838256,0.0001689404,0.0003565366,0.0001547573,0.0005313364,0.003133928],"category_scores_gemma":[0.00009633546,0.00008453112,0.0002484609,0.0001729955,0.0002780124,0.0002706822,0.0001704962,0.000537482,0.0008249411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002797564,"about_ca_system_score_gemma":0.0001953382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002406766,"about_ca_topic_score_gemma":0.0003521286,"domain_scores_codex":[0.9999135,0.00001290401,0.000005339504,0.00001666087,0.00003412718,0.00001746139],"domain_scores_gemma":[0.9999533,0.000007560559,0.00001309142,0.00000301637,0.00001027214,0.00001280699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004100291,0.00005155383,0.0003201772,0.000377717,0.00001171123,0.000281786,0.0000249589,0.00006958124,0.9815853,0.0004657871,0.001913505,0.01448794],"study_design_scores_gemma":[0.0001043607,0.001710279,0.02227462,0.00009439249,0.0001186011,0.003175853,0.0001408044,0.001643586,0.8707447,0.001009427,0.09896269,0.00002068933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7494984,0.188606,0.01504071,0.006054805,0.002901569,0.0002673166,0.001258541,0.001043063,0.03532954],"genre_scores_gemma":[0.8897289,0.06447098,0.008500907,0.002976659,0.001256101,0.0002378632,0.0008580773,0.000171372,0.0317991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003133928,"threshold_uncertainty_score":0.01048404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01708600435320802,"score_gpt":0.2228268964143986,"score_spread":0.2057408920611906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}