{"id":"W4281863931","doi":"10.1093/neuonc/noac079.472","title":"NFB-08. TRAM-01: A Phase 2 study of trametinib for pediatric patients with neurofibromatosis type 1 and plexiform neurofibromas","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"IWK Foundation; BC Children's Hospital; Centre Hospitalier Universitaire de Sherbrooke; Hospital for Sick Children; Alberta Children's Hospital; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Neurofibromatosis; Trametinib; Adverse effect; Dysgeusia; Surgery; Internal medicine; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001166491,0.0009731274,0.001061682,0.0002735672,0.0002421167,0.0005917958,0.0005964109,0.0007301039,0.002160953],"category_scores_gemma":[0.0005093463,0.0003773279,0.0006603436,0.0002996603,0.0004111293,0.0005408353,0.0002745997,0.001998247,0.000540017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007808581,"about_ca_system_score_gemma":0.001389927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001146742,"about_ca_topic_score_gemma":0.002661579,"domain_scores_codex":[0.999791,0.00008600573,0.00001170221,0.00003580871,0.00003185227,0.00004377257],"domain_scores_gemma":[0.999644,0.00004051657,0.00007902797,0.00001983249,0.00002529239,0.000191324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4346206,0.1076693,0.03514811,0.001663706,0.002475132,0.001437151,0.0007611482,0.004958382,0.08240908,0.0006323864,0.01141086,0.3168141],"study_design_scores_gemma":[0.4695518,0.4500517,0.05642322,0.00009376845,0.0007199532,0.003008612,0.0001290983,0.003760224,0.007988049,0.0002175326,0.008006009,0.00004991302],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943117,0.002327602,0.0004222019,0.0002773646,0.00003715875,0.0009207075,0.0007265845,0.00007472283,0.0009019794],"genre_scores_gemma":[0.9888709,0.00223099,0.002353636,0.0005497345,0.00007213671,0.001837778,0.002406183,0.00002925143,0.001649273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002160953,"threshold_uncertainty_score":0.007229149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02761007312132264,"score_gpt":0.3290674652133306,"score_spread":0.301457392092008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}