{"id":"W4281863931","doi":"10.1093/neuonc/noac079.472","title":"NFB-08. TRAM-01: A Phase 2 study of trametinib for pediatric patients with neurofibromatosis type 1 and plexiform neurofibromas","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"IWK Foundation; BC Children's Hospital; Centre Hospitalier Universitaire de Sherbrooke; Hospital for Sick Children; Alberta Children's Hospital; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Neurofibromatosis; Trametinib; Adverse effect; Dysgeusia; Surgery; Internal medicine; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001446984,0.0002817919,0.0006615025,0.0003749752,0.0002483448,0.00001387507,0.0001734513,0.00006061394,0.0001061239],"category_scores_gemma":[0.000262848,0.0002338291,0.00008031733,0.0008054078,0.00009437575,0.00008468273,0.0001938179,0.000392189,0.000005306897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008504043,"about_ca_system_score_gemma":0.0003540288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001873425,"about_ca_topic_score_gemma":0.000007931502,"domain_scores_codex":[0.9974696,0.0003124804,0.0004540198,0.000644242,0.0005843198,0.0005353093],"domain_scores_gemma":[0.9981812,0.0006373252,0.0002467746,0.0003978086,0.0001870224,0.0003498702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1148574,0.1033475,0.6224782,0.0009745242,0.0008137657,0.003358971,0.003521716,0.00005778019,0.08487016,0.00008331234,0.008166037,0.05747065],"study_design_scores_gemma":[0.117292,0.6675537,0.1931916,0.000009817924,0.001222568,0.000473616,0.0008298144,0.0001790926,0.003317401,0.0000437369,0.01547428,0.0004123698],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955124,0.00003963335,0.000002989851,0.0003250281,0.000257304,0.003357618,0.0001476889,0.00006999294,0.0002873497],"genre_scores_gemma":[0.9987449,0.00002073085,0.0002176475,0.0003304508,0.00006164716,0.0004382782,0.00007203179,0.00007915113,0.00003514252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5642062,"threshold_uncertainty_score":0.9535273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02761007312132264,"score_gpt":0.3290674652133306,"score_spread":0.301457392092008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}