{"id":"W4281865532","doi":"10.1016/j.omtm.2022.05.006","title":"Selective B cell depletion upon intravenous infusion of replication-incompetent anti-CD19 CAR lentivirus","year":2022,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"BC Cancer Agency","keywords":"CD19; Population; Transduction (biophysics); Transgene; Biology; Chimeric antigen receptor; Genetic enhancement; Virology; Vesicular stomatitis virus; B cell; Viral vector; Molecular biology; Immunology; T cell; Immune system; Virus; Medicine; Antibody; Gene; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002945468,0.0004537807,0.000424881,0.0004807294,0.0001861564,0.0004014016,0.0003718573,0.0003558278,0.001125768],"category_scores_gemma":[0.0001448508,0.0002092228,0.0002386709,0.0001869641,0.0003121471,0.0002414558,0.0002194383,0.001313988,0.0005267607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002779006,"about_ca_system_score_gemma":0.0002768291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003952111,"about_ca_topic_score_gemma":0.0006878335,"domain_scores_codex":[0.9997179,0.00003564501,0.000018791,0.0000593881,0.00006244253,0.0001058333],"domain_scores_gemma":[0.999817,0.00003403197,0.00004569931,0.00003196551,0.00001631414,0.00005515313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001558856,0.0001512741,0.0001700903,0.00002728266,0.00000442084,0.00003531117,0.00002823695,0.00006431412,0.9961975,0.00009557613,0.00008761512,0.002982578],"study_design_scores_gemma":[0.00006440539,0.0009811157,0.002838518,0.00001037953,0.00001793334,0.0001997632,0.00001116439,0.001342606,0.992098,0.00005244957,0.002378784,0.000004798429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890772,0.001363139,0.005449083,0.00008014366,0.00004621647,0.0002721107,0.000529123,0.0005253582,0.002657674],"genre_scores_gemma":[0.9850619,0.000915307,0.007597643,0.0001315517,0.00003157413,0.0003940173,0.0008210673,0.0001118417,0.004935086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001125768,"threshold_uncertainty_score":0.003766119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07497779339291938,"score_gpt":0.4288613776569801,"score_spread":0.3538835842640607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}