{"id":"W4281866785","doi":"10.1021/acs.molpharmaceut.1c00909","title":"A Polyplex in a Shell: The Effect of Poly(aspartic acid)-Mediated Calcium Carbonate Mineralization on Polyplexes Properties and Transfection Efficiency","year":2022,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Mineralization (soil science); Transfection; Chemistry; Aspartic acid; Calcium; Calcium carbonate; Cationic polymerization; Biophysics; Chemical engineering; Biochemistry; Organic chemistry; Gene; Biology; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002730545,0.0001613087,0.0001462357,0.00009431342,0.00009572886,0.00001421339,0.0001520997,0.00005374233,0.00001024675],"category_scores_gemma":[0.0000414372,0.0001234319,0.00006845254,0.000229344,0.00009377414,0.000003720167,0.00008350387,0.0001598131,0.000001038801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002233107,"about_ca_system_score_gemma":0.00003424676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001346487,"about_ca_topic_score_gemma":0.00002550184,"domain_scores_codex":[0.9987666,0.0003523307,0.0002090161,0.0002539633,0.0002004036,0.0002176613],"domain_scores_gemma":[0.9996737,0.00001587276,0.0000569255,0.0001865641,0.00002503229,0.00004193725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005022294,0.00006214814,0.002704636,0.00003784796,0.00003868356,0.000008583051,0.0002396875,0.00318615,0.9919743,0.00001088444,0.00002379997,0.001211058],"study_design_scores_gemma":[0.001001179,0.001361915,0.0006129463,0.00001358705,0.00004894348,0.00001622546,0.00007225122,0.01082408,0.9852555,0.000003319081,0.0006510485,0.0001390371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926272,0.00620876,0.0002778053,0.0002234124,0.0001220653,0.0003968625,0.00002156837,0.000009975937,0.0001123355],"genre_scores_gemma":[0.9992023,0.0001291814,0.000004655492,0.0004231645,0.00002306403,0.00009379967,0.0000465136,0.00002087867,0.00005643483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007637927,"threshold_uncertainty_score":0.5033407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02215234206921948,"score_gpt":0.2712063210162916,"score_spread":0.2490539789470721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}