{"id":"W4281866785","doi":"10.1021/acs.molpharmaceut.1c00909","title":"A Polyplex in a Shell: The Effect of Poly(aspartic acid)-Mediated Calcium Carbonate Mineralization on Polyplexes Properties and Transfection Efficiency","year":2022,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Mineralization (soil science); Transfection; Chemistry; Aspartic acid; Calcium; Calcium carbonate; Cationic polymerization; Biophysics; Chemical engineering; Biochemistry; Organic chemistry; Gene; Biology; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002807051,0.0003584255,0.0002383071,0.000162244,0.0001291432,0.0003853413,0.0002074042,0.0003888728,0.0006216487],"category_scores_gemma":[0.0005791225,0.000184936,0.0001789515,0.0001605342,0.0002690109,0.0003253229,0.0002048264,0.0004185642,0.000184168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003294192,"about_ca_system_score_gemma":0.0002644899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009295825,"about_ca_topic_score_gemma":0.001040221,"domain_scores_codex":[0.9997137,0.00004254576,0.00004314444,0.0001070274,0.00006257097,0.00003093541],"domain_scores_gemma":[0.9995533,0.0001512805,0.0001269402,0.0000333977,0.00005389567,0.00008125759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005830447,0.00001346014,0.00004379879,0.00002689479,0.000003948833,0.00002187786,0.00001312034,0.00005597523,0.9989292,0.00003244984,0.00001234193,0.0007885861],"study_design_scores_gemma":[0.000005172498,0.0001000475,0.0002800041,0.000001096626,0.000006266302,0.00003840952,0.000002340287,0.0005741638,0.9986274,0.000006270056,0.0003560323,0.000002829097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925885,0.0006244741,0.005393371,0.00006644346,0.00002898033,0.00004695305,0.0001136995,0.0001035395,0.001033957],"genre_scores_gemma":[0.9912447,0.0003348642,0.006446751,0.00003877781,0.00000621464,0.00002845738,0.000169968,0.00004837311,0.00168187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009295825,"threshold_uncertainty_score":0.002390146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02215234206921948,"score_gpt":0.2712063210162916,"score_spread":0.2490539789470721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}