{"id":"W4281874745","doi":"10.1101/2022.05.27.493751","title":"Huntingtin S421 phosphorylation increases kinesin and dynein engagement on early endosomes and lysosomes","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Endosome; Dynein; Kinesin; Cell biology; Huntingtin; Microtubule; Motor protein; Biology; Huntingtin Protein; Dynactin; Chemistry; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009522149,0.0002111114,0.0002128378,0.000146818,0.0001335547,0.0003491922,0.0001179355,0.0002202514,0.002099844],"category_scores_gemma":[0.00009547935,0.0001353062,0.0002055653,0.0001223039,0.0001365002,0.0001507875,0.0002195666,0.0002691995,0.0002993123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002437327,"about_ca_system_score_gemma":0.0001510607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008010154,"about_ca_topic_score_gemma":0.000849809,"domain_scores_codex":[0.9998783,0.00001393384,0.00001255034,0.00002774343,0.00003462902,0.00003287326],"domain_scores_gemma":[0.9998795,0.00002215977,0.00003305879,0.00001077308,0.000013893,0.0000406354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001023977,0.0000156384,0.0001478453,0.00001609915,0.000002849413,0.00002641883,0.0000067253,0.00002227818,0.9993134,0.00002526741,0.00002112561,0.0002998916],"study_design_scores_gemma":[0.000014463,0.0001510158,0.01143402,0.000005337512,0.000007651308,0.0001172929,0.0000333853,0.0005716091,0.9868955,0.00002113227,0.0007445333,0.000004055975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982199,0.0005138245,0.0002914515,0.00003483284,0.00001174459,0.000007584425,0.0001630846,0.00002363566,0.0007338753],"genre_scores_gemma":[0.9970443,0.0002965081,0.0004144541,0.00003111689,0.000004140179,0.00001560313,0.0001776283,0.00001422589,0.002002173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002099844,"threshold_uncertainty_score":0.007024646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02311660778087121,"score_gpt":0.2352304162293934,"score_spread":0.2121138084485222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}