{"id":"W4281886541","doi":"10.1042/bcj20220170","title":"Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators","year":2022,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"AMPK; Gluconeogenesis; Endocrinology; Internal medicine; Glucagon; Chemistry; AMP-activated protein kinase; Glucose uptake; Protein kinase A; Metabolism; Phosphorylation; Biochemistry; Biology; Insulin; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001550427,0.0003077809,0.0002900104,0.00028769,0.0001278574,0.0002802457,0.0002233493,0.0002098991,0.002643523],"category_scores_gemma":[0.0001090628,0.0001165558,0.0002963411,0.0002882259,0.0002194824,0.0002164798,0.0001671295,0.0007212957,0.0005107406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001981587,"about_ca_system_score_gemma":0.0002073035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001754623,"about_ca_topic_score_gemma":0.0004160796,"domain_scores_codex":[0.999916,0.00001891875,0.00001135909,0.00001818927,0.0000156229,0.00002003021],"domain_scores_gemma":[0.999939,0.00001945504,0.00001498555,0.00000664451,0.000004987193,0.00001488701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001215664,0.0002721673,0.0002299072,0.0002812282,0.0000213906,0.0000963881,0.00001908136,0.0001624829,0.9887783,0.000442722,0.0001719423,0.008308871],"study_design_scores_gemma":[0.0001222784,0.001836858,0.002324899,0.00001783839,0.00004064026,0.0002046067,0.00003616761,0.0004076136,0.9892463,0.0001092322,0.005643695,0.000009733015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796213,0.008437931,0.005353332,0.0004456234,0.0001680205,0.00009722599,0.000851539,0.0001287764,0.004896261],"genre_scores_gemma":[0.979936,0.008458494,0.006487434,0.0002156547,0.0000692966,0.0001390782,0.001232683,0.00003659525,0.00342478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002643523,"threshold_uncertainty_score":0.008843482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01156720084541392,"score_gpt":0.2544469833658526,"score_spread":0.2428797825204387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}