{"id":"W4281887240","doi":"10.1016/j.biopha.2022.113230","title":"Breaking boundaries: Pan BETi disrupt 3D chromatin structure, BD2-selective BETi are strictly epigenetic transcriptional regulators","year":2022,"lang":"en","type":"article","venue":"Biomedicine & Pharmacotherapy","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada)","funders":"","keywords":"Chromatin; BRD4; Chromatin immunoprecipitation; Biology; Cell biology; Bromodomain; Epigenetics; Chromatin remodeling; Transcription (linguistics); RNA polymerase II; Transcription factor; DNA damage; DNA repair; Promoter; Molecular biology; DNA; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001470821,0.0002640502,0.000312153,0.0001495187,0.0001731341,0.00032343,0.00022427,0.000237684,0.003320309],"category_scores_gemma":[0.0001605157,0.0001718265,0.0002253783,0.0001383219,0.0002027257,0.0002071514,0.0002478687,0.0005867889,0.0007021496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002251635,"about_ca_system_score_gemma":0.0001369756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003632717,"about_ca_topic_score_gemma":0.0006130697,"domain_scores_codex":[0.9998335,0.00001558712,0.00001060841,0.00005331121,0.00005509773,0.00003189734],"domain_scores_gemma":[0.999913,0.00001191691,0.00002758449,0.000009480305,0.00001087749,0.00002724056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001544735,0.00001612104,0.0002182228,0.00004666103,0.000007235301,0.00001656619,0.000005893843,0.00005268492,0.9979134,0.00008301705,0.00007466516,0.001410886],"study_design_scores_gemma":[0.00003635714,0.0002375024,0.002713099,0.000007202803,0.00002304783,0.0002423127,0.00001851429,0.0006581102,0.9881757,0.00007014622,0.007813125,0.000004784202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787536,0.004929949,0.009160111,0.0002199853,0.0001186711,0.0000753944,0.001455839,0.0002624891,0.005024096],"genre_scores_gemma":[0.9879473,0.001384078,0.004170866,0.0002448186,0.00002143995,0.00007674639,0.001687672,0.00007281428,0.004394173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003320309,"threshold_uncertainty_score":0.0111075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009438346501894856,"score_gpt":0.267718503684943,"score_spread":0.2582801571830482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}