{"id":"W4281887240","doi":"10.1016/j.biopha.2022.113230","title":"Breaking boundaries: Pan BETi disrupt 3D chromatin structure, BD2-selective BETi are strictly epigenetic transcriptional regulators","year":2022,"lang":"en","type":"article","venue":"Biomedicine & Pharmacotherapy","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada)","funders":"","keywords":"Chromatin; BRD4; Chromatin immunoprecipitation; Biology; Cell biology; Bromodomain; Epigenetics; Chromatin remodeling; Transcription (linguistics); RNA polymerase II; Transcription factor; DNA damage; DNA repair; Promoter; Molecular biology; DNA; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002586301,0.0003578482,0.0003185554,0.0002253195,0.0007357126,0.0000648386,0.000376743,0.0001140792,0.001423825],"category_scores_gemma":[0.00002223508,0.0003409117,0.0001493087,0.0005613946,0.0003541205,0.00001315584,0.00007054461,0.0002792193,0.00000397615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000134669,"about_ca_system_score_gemma":0.0002870123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007795433,"about_ca_topic_score_gemma":0.00001896362,"domain_scores_codex":[0.9975868,0.0002272938,0.0004793316,0.000627165,0.0006361044,0.0004433074],"domain_scores_gemma":[0.9990622,0.00001645172,0.0002965012,0.0003393698,0.0001099983,0.0001754497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002395075,0.0001391395,0.002308884,0.00002406688,0.0001868338,0.000007093074,0.0003299603,0.00003282526,0.9660281,0.00005960323,0.01096215,0.01968185],"study_design_scores_gemma":[0.002793911,0.0008336314,0.01387612,0.00002014936,0.00005049831,0.00005028313,0.0002317719,0.0001331681,0.4398687,0.0001205932,0.5416055,0.0004156737],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987542,0.006116931,0.002054868,0.001252907,0.001271536,0.0007762712,0.0006169807,0.00007963014,0.0002889182],"genre_scores_gemma":[0.993773,0.0002359886,0.0004675723,0.002687563,0.001182011,0.0001339694,0.0008951962,0.00007334745,0.0005513094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5306433,"threshold_uncertainty_score":0.9999043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009438346501894856,"score_gpt":0.267718503684943,"score_spread":0.2582801571830482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}