{"id":"W4281913377","doi":"10.3390/pharmaceutics14061163","title":"Enalapril and Enalaprilat Pharmacokinetics in Children with Heart Failure Due to Dilated Cardiomyopathy and Congestive Heart Failure after Administration of an Orodispersible Enalapril Minitablet (LENA-Studies)","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Apotex Pharmachem (Canada)","funders":"Division of Mathematical Sciences; European Commission","keywords":"Enalapril; Enalaprilat; Medicine; Heart failure; Dilated cardiomyopathy; Pharmacokinetics; Active metabolite; Cmax; Dosing; ACE inhibitor; Internal medicine; Cardiology; Cardiomyopathy; Heart disease; Angiotensin-converting enzyme; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000766939,0.0002897346,0.0006785661,0.0002019988,0.0001439431,0.0002520079,0.0001301627,0.0002695149,0.0004283101],"category_scores_gemma":[0.001294666,0.0001837562,0.0003858134,0.0002626542,0.0003158778,0.0003578079,0.0001902594,0.00057267,0.00009509454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003403116,"about_ca_system_score_gemma":0.0004241218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000697528,"about_ca_topic_score_gemma":0.001347944,"domain_scores_codex":[0.9996616,0.0001544215,0.00003337657,0.00005272107,0.00005739351,0.00004053123],"domain_scores_gemma":[0.9992067,0.0002648246,0.0003477802,0.00003050394,0.00004162366,0.0001085869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0755537,0.002754692,0.6993273,0.0008924554,0.0005379739,0.003923652,0.001445068,0.003728502,0.08724105,0.00039208,0.001162932,0.1230405],"study_design_scores_gemma":[0.002595063,0.08399671,0.8787621,0.00005800766,0.000373307,0.005944479,0.0003480709,0.001860779,0.0214039,0.0000958238,0.004528214,0.00003350643],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987519,0.0007010078,0.0002041573,0.00002273593,0.000003080667,0.00002793613,0.00009338662,0.000006092575,0.000189659],"genre_scores_gemma":[0.9983771,0.0006217556,0.0005623795,0.00004881754,0.000007998451,0.00004426542,0.0002348867,0.000003261999,0.00009953955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000766939,"threshold_uncertainty_score":0.004055977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03085048581274667,"score_gpt":0.3406707437093048,"score_spread":0.3098202578965581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}