{"id":"W4281913377","doi":"10.3390/pharmaceutics14061163","title":"Enalapril and Enalaprilat Pharmacokinetics in Children with Heart Failure Due to Dilated Cardiomyopathy and Congestive Heart Failure after Administration of an Orodispersible Enalapril Minitablet (LENA-Studies)","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Apotex Pharmachem (Canada)","funders":"Division of Mathematical Sciences; European Commission","keywords":"Enalapril; Enalaprilat; Medicine; Heart failure; Dilated cardiomyopathy; Pharmacokinetics; Active metabolite; Cmax; Dosing; ACE inhibitor; Internal medicine; Cardiology; Cardiomyopathy; Heart disease; Angiotensin-converting enzyme; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007731251,0.0004407171,0.0008881633,0.0002397897,0.0002721112,0.00004705128,0.0001240859,0.00008400518,0.0001918718],"category_scores_gemma":[0.0001206486,0.0003878663,0.00007590591,0.0007374269,0.0002983076,0.0002971123,0.0003898707,0.000836172,0.000004212726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001384491,"about_ca_system_score_gemma":0.0001561527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000502467,"about_ca_topic_score_gemma":0.0001023363,"domain_scores_codex":[0.997228,0.0003404167,0.0005297814,0.000697972,0.000611121,0.0005927567],"domain_scores_gemma":[0.9984689,0.0002772595,0.0001599428,0.0002788714,0.0002539094,0.0005611569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01285767,0.001330661,0.9355659,0.000748966,0.002118639,0.0004750627,0.004800199,0.00102976,0.03328446,0.00003936174,0.004956605,0.002792655],"study_design_scores_gemma":[0.02299687,0.00781554,0.3399768,0.0004567816,0.00531753,0.008216528,0.01107736,0.007035161,0.107256,0.00008097079,0.4875514,0.002219115],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785281,0.006441193,0.00001141301,0.01310871,0.000108271,0.00135179,0.000330686,0.00004950652,0.00007030634],"genre_scores_gemma":[0.9926271,0.0008904844,0.002340773,0.003635087,0.0001592632,0.0001941381,0.00006214268,0.00005391841,0.00003708551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5955892,"threshold_uncertainty_score":0.9998573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03085048581274667,"score_gpt":0.3406707437093048,"score_spread":0.3098202578965581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}