{"id":"W4281934052","doi":"10.1002/pros.24356","title":"Androgen receptor genomic alterations and treatment resistance in metastatic prostate cancer","year":2022,"lang":"en","type":"review","venue":"The Prostate","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Prostate Cancer Foundation","keywords":"Prostate cancer; Androgen receptor; Medicine; Prostate; Oncology; Prostate disease; Androgen; Internal medicine; Cancer; Receptor; Cancer research; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004435738,0.000519626,0.001411288,0.0002768605,0.0003469495,0.00008682382,0.0001722405,0.0000617146,0.0005051128],"category_scores_gemma":[0.00002635338,0.0002900883,0.0002325773,0.0005890265,0.0002025308,0.00007992898,0.0001496364,0.0004863902,0.00004300674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001554185,"about_ca_system_score_gemma":0.00148904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000281109,"about_ca_topic_score_gemma":0.0006236524,"domain_scores_codex":[0.997389,0.0004151718,0.0006325569,0.0006480666,0.0003254467,0.0005898208],"domain_scores_gemma":[0.9987381,0.0002397569,0.0002555196,0.0005560938,0.00004056249,0.0001699522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005849256,0.0002637157,0.0001911887,0.00701643,0.001036373,0.0002478871,0.004291894,0.000003308646,0.000008601778,0.00007164633,0.001212941,0.9850711],"study_design_scores_gemma":[0.001942053,0.000337863,0.00003325823,0.002453681,0.001144976,0.0000436158,0.0001111602,0.000007429698,0.000008922422,0.0001455146,0.9934996,0.0002718657],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001169499,0.9888936,2.683049e-7,0.001303652,0.0001350473,0.006706345,0.00127216,0.00005909548,0.0004603498],"genre_scores_gemma":[0.0000355648,0.9628357,0.0001539693,0.00006261483,0.00007850026,0.0080284,0.0008363995,0.0001020131,0.02786682],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9922867,"threshold_uncertainty_score":0.9999551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09868511844137028,"score_gpt":0.3896992534177602,"score_spread":0.2910141349763899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}