{"id":"W4281934192","doi":"10.1056/nejmoa2206038","title":"Tirzepatide Once Weekly for the Treatment of Obesity","year":2022,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":3207,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; York University","funders":"Eli Lilly and Company","keywords":"Obesity; Agonist; Medicine; Glucagon-like peptide-1; Endocrinology; Diabetes mellitus; Receptor; Internal medicine; Disease; Type 2 diabetes","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006970915,0.000464729,0.001131613,0.0003988152,0.0002092579,0.0003270694,0.0003739516,0.0006001745,0.004160831],"category_scores_gemma":[0.000703267,0.0002520562,0.001004387,0.0002565914,0.0002894074,0.0003439093,0.0001704391,0.001257716,0.0005464731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002336227,"about_ca_system_score_gemma":0.0003365327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004067159,"about_ca_topic_score_gemma":0.0007699596,"domain_scores_codex":[0.9997615,0.0001034246,0.00002785288,0.00004257394,0.00003491991,0.00002969477],"domain_scores_gemma":[0.9997076,0.00008847293,0.0001034283,0.0000199523,0.00001866719,0.00006175228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5712755,0.01508818,0.002899924,0.007637248,0.003196098,0.0003467428,0.0001416904,0.001180897,0.04411827,0.000468136,0.004731926,0.3489154],"study_design_scores_gemma":[0.8283069,0.146559,0.01084515,0.0003848037,0.001354308,0.0006532249,0.00003990902,0.00120564,0.004489093,0.0002499367,0.00587681,0.00003535635],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9443183,0.04379579,0.002238391,0.001196288,0.0007673724,0.002926293,0.0006965186,0.0004007304,0.003660309],"genre_scores_gemma":[0.9808624,0.01159347,0.002380369,0.0009233916,0.0002695493,0.001650286,0.0003831917,0.00002280348,0.001914602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004160831,"threshold_uncertainty_score":0.01391935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02657164938863743,"score_gpt":0.2838889725144743,"score_spread":0.2573173231258368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}