{"id":"W4281940442","doi":"10.1136/jitc-2022-004885","title":"Baseline circulating unswitched memory B cells and B-cell related soluble factors are associated with overall survival in patients with clear cell renal cell carcinoma treated with nivolumab within the NIVOREN GETUG-AFU 26 study","year":2022,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Université de Paris; Unicancer; Bristol-Myers Squibb; Sorbonne Université; Ligue Contre le Cancer; Institut National de la Santé et de la Recherche Médicale; Institute of Cancer Research; Institut National Du Cancer","keywords":"Nivolumab; Medicine; Renal cell carcinoma; Internal medicine; Oncology; Flow cytometry; Immune system; Clear cell renal cell carcinoma; Immunotherapy; B cell; Prospective cohort study; Immunology; Antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008606997,0.0002204632,0.000388228,0.0002104028,0.0001771627,0.0004156152,0.0002197647,0.0002900632,0.0006830023],"category_scores_gemma":[0.001005649,0.0001257548,0.0003034336,0.0002200197,0.0001956967,0.0002498592,0.0002138727,0.0004587373,0.0001211108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001846808,"about_ca_system_score_gemma":0.0001982233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000498793,"about_ca_topic_score_gemma":0.0007453795,"domain_scores_codex":[0.9997109,0.000109581,0.00002554944,0.00006680602,0.00004730403,0.00003996382],"domain_scores_gemma":[0.99931,0.0001500947,0.0002666369,0.00007163177,0.00006322729,0.0001384144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01031445,0.0002104966,0.9734726,0.00003940787,0.0002263715,0.0000688163,0.00007706898,0.0003147224,0.008426574,0.0000199673,0.0002345412,0.006594971],"study_design_scores_gemma":[0.0002097845,0.001959012,0.995586,0.000004894238,0.0001111829,0.0002466302,0.00004888297,0.000521694,0.0009509859,0.00002306089,0.0003325631,0.00000530796],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995642,0.0002125174,0.00004556271,0.000009555846,0.000002027578,0.000004749106,0.00007547199,0.000002719925,0.00008320649],"genre_scores_gemma":[0.9996402,0.00003686495,0.00004856613,0.00001296025,0.000005315809,0.000005953196,0.0001942232,0.00000121925,0.00005467836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008606997,"threshold_uncertainty_score":0.004551888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01371519600306477,"score_gpt":0.2327266696596693,"score_spread":0.2190114736566046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}