{"id":"W4281946301","doi":"10.1200/jco.2022.40.16_suppl.8013","title":"Efficacy and safety of teclistamab (tec), a B-cell maturation antigen (BCMA) x CD3 bispecific antibody, in patients (pts) with relapsed/refractory multiple myeloma (RRMM) after exposure to other BCMA-targeted agents.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"","keywords":"Medicine; Internal medicine; Cytokine release syndrome; Cohort; Oncology; Clinical endpoint; Gastroenterology; Chimeric antigen receptor; Surgery; Clinical trial; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008502493,0.0003336768,0.0006817046,0.0002641897,0.0002061603,0.0005101611,0.0002342247,0.0004362456,0.0009669831],"category_scores_gemma":[0.0008983587,0.0001768928,0.0007930486,0.0002917119,0.0003412799,0.0004080494,0.0002679205,0.0009389562,0.0002809686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008275325,"about_ca_system_score_gemma":0.0007193067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009392822,"about_ca_topic_score_gemma":0.001457514,"domain_scores_codex":[0.9997321,0.0001148965,0.00002016741,0.00004875688,0.00003912401,0.00004501566],"domain_scores_gemma":[0.9994809,0.00008982137,0.0001819316,0.00003692007,0.00003258439,0.0001779152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.598027,0.01578019,0.1148164,0.0005831338,0.001307645,0.0005044854,0.0004524626,0.004828445,0.05000899,0.0001468692,0.001956058,0.2115883],"study_design_scores_gemma":[0.05391049,0.6472001,0.2814327,0.00005976877,0.001236476,0.0009797161,0.0001198969,0.003040803,0.007731895,0.0001542418,0.00410027,0.00003360333],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978092,0.0010038,0.0001283509,0.00006628939,0.00001074877,0.0001396191,0.0003266474,0.00001575172,0.0004997278],"genre_scores_gemma":[0.9985908,0.0003499654,0.0001283087,0.00008048372,0.00002437058,0.00008204943,0.0004660399,0.000003126981,0.0002748224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009669831,"threshold_uncertainty_score":0.006004214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05040499462910015,"score_gpt":0.3896877297100008,"score_spread":0.3392827350809006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}