{"id":"W4281953957","doi":"10.1093/neuonc/noac079.371","title":"LGG-60. Development and implementation of a complementary diagnostic tool to detect targetable pathways in pediatric glioma patients","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation","funders":"","keywords":"Glioma; PI3K/AKT/mTOR pathway; MAPK/ERK pathway; Cancer research; Concordance; Medicine; Transcriptome; Biology; Signal transduction; Internal medicine; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001433538,0.0006320004,0.0005815806,0.0009455155,0.0002217561,0.0009126354,0.0004990046,0.0007498769,0.001520818],"category_scores_gemma":[0.001426527,0.0002153371,0.0003795534,0.0005288299,0.0003325716,0.0003807267,0.0005509991,0.000562423,0.001220842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008473143,"about_ca_system_score_gemma":0.0009100209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00194396,"about_ca_topic_score_gemma":0.002627823,"domain_scores_codex":[0.999298,0.0001508948,0.00004494345,0.000193392,0.0002230136,0.00008984186],"domain_scores_gemma":[0.9993782,0.00009239175,0.0001152469,0.00004706828,0.0002120467,0.0001550949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004025381,0.0007265267,0.4820446,0.0005110301,0.0001673611,0.001051343,0.000391581,0.001823465,0.2064238,0.0007041422,0.00979382,0.292337],"study_design_scores_gemma":[0.0006030281,0.007477559,0.6585598,0.0004130122,0.000482973,0.004623209,0.0007102914,0.01664825,0.2403319,0.001473136,0.06856843,0.0001084341],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9587559,0.005717923,0.01429974,0.001978059,0.0002469566,0.0009433664,0.006439195,0.002462631,0.009156162],"genre_scores_gemma":[0.9395373,0.001879435,0.04510494,0.001688595,0.0000746166,0.000776102,0.008279273,0.0002083164,0.002451453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00194396,"threshold_uncertainty_score":0.007581353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01930993807644418,"score_gpt":0.2863821505463214,"score_spread":0.2670722124698772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}