{"id":"W4281954158","doi":"10.3390/cancers14112751","title":"Hypoxia Selectively Increases a SMAD3 Signaling Axis to Promote Cancer Cell Invasion","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Université de Sherbrooke","keywords":"SMAD; Cancer research; Transforming growth factor; Motility; Metastasis; Tumor progression; Hypoxia (environmental); Carcinogenesis; Signal transduction; Cancer cell; Cell biology; Biology; Cancer; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008542296,0.0002380789,0.0001727154,0.0001368461,0.0001236529,0.0001813069,0.00006923087,0.000146235,0.002311634],"category_scores_gemma":[0.00004570707,0.00009685497,0.0003077586,0.0000739069,0.0001233429,0.0001256235,0.0001515414,0.0003870416,0.0003084777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001871976,"about_ca_system_score_gemma":0.0002275581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004505464,"about_ca_topic_score_gemma":0.001448287,"domain_scores_codex":[0.99994,0.00001052513,0.000003615874,0.00001047849,0.0000157724,0.00001959407],"domain_scores_gemma":[0.9999688,0.000004956757,0.000007295773,0.000002855099,0.000004181762,0.00001203324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001352007,0.00002715829,0.0001933311,0.00004374621,0.000006424764,0.00003217895,0.000007826206,0.00003601232,0.9977616,0.00009496195,0.0000853739,0.001576129],"study_design_scores_gemma":[0.00002605528,0.0004834754,0.01242686,0.00000977179,0.00002670294,0.0003082391,0.00004551073,0.000810385,0.9796917,0.0001155645,0.006050804,0.000004830947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812865,0.006514052,0.00500247,0.0005950755,0.0001252035,0.0000430414,0.0005183117,0.0001797835,0.005735513],"genre_scores_gemma":[0.9933112,0.002029448,0.001303571,0.0001570634,0.00002166959,0.00002445302,0.0002774716,0.00001764944,0.002857543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002311634,"threshold_uncertainty_score":0.007733226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01288036448915914,"score_gpt":0.2487565390721549,"score_spread":0.2358761745829958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}