{"id":"W4281954490","doi":"10.1101/2022.05.30.22275781","title":"Local genetic correlations exist among neurodegenerative and neuropsychiatric diseases","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Institutes of Health; Institut de Valorisation des Données; Medical Research Council; Eisai; University College London; UK Research and Innovation; Wolfson Foundation; UK Dementia Research Institute; National Institute for Health and Care Research; Michael J. Fox Foundation for Parkinson's Research","keywords":"Schizophrenia (object-oriented programming); Disease; Lewy body; Biology; Dementia; Genome-wide association study; Genetic architecture; Bipolar disorder; Neuroscience; Genetics; Gene; Quantitative trait locus; Medicine; Psychiatry; Single-nucleotide polymorphism; Cognition; Genotype; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001716178,0.0004584645,0.0008330092,0.001645988,0.0004044801,0.001026253,0.0003530353,0.0004186165,0.003152533],"category_scores_gemma":[0.003898422,0.0002776723,0.0007338609,0.001556629,0.0009501469,0.0004072078,0.001273054,0.0006051565,0.0003598701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002417018,"about_ca_system_score_gemma":0.0003730704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009334116,"about_ca_topic_score_gemma":0.001328892,"domain_scores_codex":[0.997979,0.0006565062,0.0001429424,0.0008620793,0.0002111247,0.0001483318],"domain_scores_gemma":[0.994779,0.002243219,0.001779401,0.0007521739,0.0001525647,0.0002936087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009770301,0.00008159932,0.9254268,0.000167176,0.001831825,0.001559904,0.0003683326,0.00180129,0.04486391,0.00238701,0.0005910601,0.01994398],"study_design_scores_gemma":[0.00004021525,0.0001365224,0.9828316,0.00002994672,0.0004819977,0.00191751,0.0002356692,0.003459037,0.004840125,0.005014103,0.0009791944,0.00003411195],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987384,0.0006707918,0.009209557,0.0001564759,0.00001116261,0.00002059291,0.0008458046,0.0001777675,0.001523846],"genre_scores_gemma":[0.9968959,0.00009548437,0.002403427,0.00004162303,0.00001261663,0.00001315678,0.0003017484,0.00003007892,0.0002059728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003152533,"threshold_uncertainty_score":0.01054621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01167719487479333,"score_gpt":0.2543435995683297,"score_spread":0.2426664046935364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}