{"id":"W4281957275","doi":"10.1101/2022.06.03.494722","title":"Epigenome-wide association study analysis of calorie restriction in humans, CALERIE™ Trial analysis","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Evelyn F. McKnight Brain Research Foundation; American Academy of Neurology; American Brain Foundation; McKnight Foundation; Brain Research Foundation","keywords":"dNaM; Epigenome; Calorie restriction; CpG site; DNA methylation; Internal medicine; Waist; Physiology; Medicine; Endocrinology; Biology; Body mass index; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"observational","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"observational","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004856772,0.0004160175,0.001417069,0.0006942823,0.0004706061,0.0007814287,0.000588057,0.0005844657,0.003120173],"category_scores_gemma":[0.008658414,0.0002293768,0.001795764,0.002238562,0.0003262752,0.0005177554,0.0004506005,0.001038245,0.0001870292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002237026,"about_ca_system_score_gemma":0.0005481779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003331735,"about_ca_topic_score_gemma":0.003266108,"domain_scores_codex":[0.9933097,0.003767493,0.0005731916,0.001662475,0.0004715957,0.0002154133],"domain_scores_gemma":[0.9945477,0.002672144,0.001237736,0.0007284384,0.0004784247,0.0003355881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01932245,0.0001380796,0.8981704,0.003026499,0.05710071,0.0002342495,0.00008996345,0.0008656879,0.00189983,0.0005889522,0.00440592,0.01415725],"study_design_scores_gemma":[0.001319301,0.00106826,0.9711738,0.0003009599,0.01959406,0.000204579,0.00008850011,0.001880546,0.0005132748,0.0008662078,0.002967925,0.00002253452],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9212866,0.04961384,0.008014355,0.00136708,0.0006753546,0.0004285459,0.01373555,0.0001264204,0.004752203],"genre_scores_gemma":[0.992811,0.001427031,0.001714636,0.0003351366,0.0001334822,0.0004176327,0.002370545,0.00002267329,0.0007678329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004856772,"threshold_uncertainty_score":0.02568531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01498575710341926,"score_gpt":0.2581157784120229,"score_spread":0.2431300213086036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}