{"id":"W4281965933","doi":"10.1101/2022.06.05.494912","title":"Induction of senescence renders cancer cells highly immunogenic","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; Centre Hospitalier Universitaire Sainte-Justine","funders":"European Regional Development Fund; Karolinska Institutet; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Vetenskapsrådet","keywords":"Senescence; MHC class I; Immune system; Biology; CD8; Cancer cell; Cytotoxic T cell; Immunology; Acquired immune system; Antigen; Cross-presentation; Context (archaeology); Antigen presentation; Major histocompatibility complex; Cancer; Cancer research; Cell biology; T cell; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001263273,0.000189432,0.00016259,0.0001310513,0.00007667642,0.0002184317,0.00007006827,0.0001911539,0.001543289],"category_scores_gemma":[0.0001029137,0.00007327685,0.0001629316,0.00007467142,0.0001557767,0.000111773,0.0001914213,0.0003288146,0.0006800441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001233091,"about_ca_system_score_gemma":0.00009441831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001078663,"about_ca_topic_score_gemma":0.00007091566,"domain_scores_codex":[0.9999142,0.0000158133,0.00000665592,0.00001564709,0.0000244441,0.00002323395],"domain_scores_gemma":[0.9998986,0.00001912564,0.00002033681,0.00002507152,0.00001189802,0.0000249429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003630561,0.00001104576,0.000111897,0.00001082691,0.00000150541,0.00002544217,0.000009244568,0.00002983819,0.9990118,0.0001249992,0.00003183273,0.0005951945],"study_design_scores_gemma":[0.00001254048,0.0003170999,0.002356409,0.000004586598,0.0000069088,0.0003727784,0.0000183011,0.000566001,0.9909468,0.0001379281,0.005258157,0.000002680012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906921,0.001196232,0.005031967,0.00009286978,0.00006816794,0.00003130584,0.0002356415,0.0001098598,0.002541807],"genre_scores_gemma":[0.9951649,0.0004240939,0.001319511,0.00006871932,0.00001764537,0.00001822347,0.0002676566,0.00002202863,0.002697276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001543289,"threshold_uncertainty_score":0.005162776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01493301102208852,"score_gpt":0.2283983599158152,"score_spread":0.2134653488937267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}