{"id":"W4281974175","doi":"10.1093/narcan/zcac016","title":"Allele-informed copy number evaluation of plasma DNA samples from metastatic prostate cancer patients: the PCF_SELECT consortium assay","year":2022,"lang":"en","type":"article","venue":"NAR Cancer","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; Foundation Medicine; Genentech; Ono Pharmaceutical; Shionogi; Astellas Pharma; National Institute for Health and Care Research; Cancer Research UK; Associazione Italiana per la Ricerca sul Cancro; Astex Pharmaceuticals; Francis Crick Institute; Rosetrees Trust; Bayer HealthCare; Sanofi; GlaxoSmithKline; Invitae; Prostate Cancer Foundation; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Amgen; Pfizer","keywords":"Prostate cancer; Allele; Biology; Single-nucleotide polymorphism; Prostate; Cancer; Allele frequency; Gene; Cancer research; Genetics; Internal medicine; Oncology; Genotype; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001578972,0.000675304,0.000391359,0.001754452,0.0004661359,0.0007984483,0.0004261894,0.000792416,0.002063259],"category_scores_gemma":[0.002998101,0.0002317235,0.0002723589,0.0007145726,0.0003760101,0.0002371803,0.0005640846,0.000509686,0.000497358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003092808,"about_ca_system_score_gemma":0.0003552057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001090813,"about_ca_topic_score_gemma":0.001878823,"domain_scores_codex":[0.9978765,0.000454048,0.0001095251,0.0006455908,0.0007558476,0.0001584329],"domain_scores_gemma":[0.9989944,0.0004112366,0.0001672506,0.0001567612,0.0001799538,0.00009038924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002389921,0.0004445933,0.2337737,0.0001947747,0.0003443116,0.0007013889,0.0004699012,0.004504197,0.6330518,0.000866545,0.003379748,0.1198791],"study_design_scores_gemma":[0.0001295665,0.001873031,0.2400733,0.00003700261,0.0001841691,0.005524452,0.0001568718,0.01842867,0.71964,0.0007766827,0.01306961,0.0001066316],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9286081,0.001535403,0.05665945,0.0004284803,0.00005889242,0.0004814278,0.005921741,0.001210235,0.005096348],"genre_scores_gemma":[0.9657682,0.0002787478,0.02836045,0.0002161285,0.00003463781,0.0003379299,0.002848929,0.00008041499,0.002074614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002063259,"threshold_uncertainty_score":0.008350492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02443670983961077,"score_gpt":0.3069160730589166,"score_spread":0.2824793632193058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}