{"id":"W4281978861","doi":"10.21203/rs.3.rs-1648303/v1","title":"STIM1-mediated SOCE Promotes Autophagy through AKT/mTOR Pathway in Hippocampal Neurons after  Ischemic Stroke","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Autophagy; Hippocampal formation; PI3K/AKT/mTOR pathway; Protein kinase B; Neuroscience; Stroke (engine); Chemistry; Cell biology; Signal transduction; Biology; Apoptosis; Engineering; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001669539,0.0002541678,0.0005754769,0.0003264009,0.0003281182,0.0004250487,0.0001603514,0.000354533,0.004366205],"category_scores_gemma":[0.0001918642,0.0001281241,0.0005200122,0.0003288538,0.0003559515,0.0004447586,0.0003653629,0.0006171186,0.0009356653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004969565,"about_ca_system_score_gemma":0.0006141944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001191407,"about_ca_topic_score_gemma":0.001781963,"domain_scores_codex":[0.9998645,0.000009545826,0.000009123349,0.00002302442,0.00002450626,0.00006916458],"domain_scores_gemma":[0.9999466,0.000004000052,0.0000116669,0.000007827869,0.00001195989,0.00001798597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006048349,0.0002470206,0.002732888,0.0007623862,0.0001804854,0.0005860014,0.000198493,0.0005928258,0.9585006,0.002219177,0.004720983,0.02321076],"study_design_scores_gemma":[0.0003152042,0.0007667567,0.07940058,0.00008537526,0.0002639552,0.0009761856,0.0006239662,0.005584781,0.8931029,0.003759741,0.01506326,0.00005733283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846269,0.003955614,0.002027969,0.0007001649,0.0003428001,0.00002077593,0.001927704,0.0002729863,0.006124961],"genre_scores_gemma":[0.9878272,0.001770472,0.001054423,0.0001539048,0.00006100359,0.00005886132,0.001459787,0.00007248273,0.007541819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004366205,"threshold_uncertainty_score":0.01460648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05175778626991612,"score_gpt":0.3820146032721585,"score_spread":0.3302568170022424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}