{"id":"W4281981040","doi":"10.1200/jco.2022.40.16_suppl.9542","title":"The prognostic impact of immune-related adverse events in real-world patients with metastatic melanoma treated with single-agent and combination immune checkpoint blockade.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary","funders":"","keywords":"Medicine; Nivolumab; Ipilimumab; Pembrolizumab; Adverse effect; Internal medicine; Oncology; Immune checkpoint; Blockade; Clinical endpoint; Proportional hazards model; Melanoma; Metastatic melanoma; Immunotherapy; Cancer; Clinical trial; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005621001,0.0001824329,0.0002138967,0.0006001313,0.0002597542,0.000536852,0.0004199004,0.0003191455,0.0009301211],"category_scores_gemma":[0.001659287,0.0001676214,0.0003361627,0.001043787,0.0002621038,0.0002510513,0.000344585,0.0004508222,0.0001312803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008332942,"about_ca_system_score_gemma":0.0006300447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01997949,"about_ca_topic_score_gemma":0.03112872,"domain_scores_codex":[0.9996643,0.00007269646,0.00004026754,0.00007430765,0.0000911544,0.00005720073],"domain_scores_gemma":[0.9984828,0.0001944206,0.0008683215,0.0000752611,0.0001174909,0.0002618172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001515695,0.000009651261,0.9989839,0.00000632407,0.0000260251,0.00003918954,0.00001176373,0.00006622113,0.00006116975,0.00000590962,0.00007866519,0.0005594977],"study_design_scores_gemma":[0.0000104162,0.00004903895,0.9993316,0.000003768787,0.00001656547,0.0001535655,0.00003875211,0.0002405695,0.00002068118,0.000009908924,0.0001230005,0.000002268948],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978408,0.0005041903,0.00005075508,0.00005111619,0.000004741858,0.000009217939,0.00120112,0.000002954649,0.0003350629],"genre_scores_gemma":[0.998964,0.00008950059,0.00004033892,0.00001812894,0.000007750423,0.000006896479,0.0008201649,7.512186e-7,0.00005251598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01997949,"threshold_uncertainty_score":0.03972638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04547724419523528,"score_gpt":0.3767580796063134,"score_spread":0.3312808354110781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}