{"id":"W4281984190","doi":"10.21203/rs.3.rs-1696532/v1","title":"SARS-CoV-2 Omicron BA.2.12.1, BA.4, and BA.5 subvariants evolved to extend antibody evasion","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Columbia College","funders":"National Institutes of Health; Regeneron Pharmaceuticals; Bill and Melinda Gates Foundation","keywords":"Evasion (ethics); Virology; Coronavirus disease 2019 (COVID-19); Antibody; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Chemistry; Biology; Medicine; Genetics; Infectious disease (medical specialty); Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.00684324,0.0008994228,0.001582859,0.002772341,0.0009339669,0.0005576669,0.00150018,0.0009498423,0.00055502],"category_scores_gemma":[0.002992182,0.0008536651,0.0004972593,0.001675562,0.000538406,0.0002259491,0.007847412,0.006142017,0.0006950627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001821193,"about_ca_system_score_gemma":0.003289352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003819499,"about_ca_topic_score_gemma":0.0004194227,"domain_scores_codex":[0.9867631,0.00164794,0.001008141,0.002891791,0.005117621,0.00257145],"domain_scores_gemma":[0.9937662,0.001079405,0.0001813145,0.00308898,0.001421951,0.0004620905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004720302,0.001165834,0.04246072,0.005226669,0.0003959682,0.002479472,0.001610743,0.000005551866,0.9029963,0.0001799051,0.02357117,0.01518735],"study_design_scores_gemma":[0.007667683,0.004520362,0.1028824,0.004564345,0.0002012513,0.0002491945,0.002423,0.001981683,0.3203789,0.001771818,0.551476,0.001883459],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726242,0.006349334,0.0002639313,0.003192104,0.0006380971,0.006436296,0.0004412352,0.0002789613,0.00977583],"genre_scores_gemma":[0.9868621,0.00116061,0.0007949269,0.006802959,0.001232468,0.001217025,0.000523234,0.0003890483,0.001017645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5826175,"threshold_uncertainty_score":0.9993914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1285461872379474,"score_gpt":0.4748514768493977,"score_spread":0.3463052896114503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}