{"id":"W4281984190","doi":"10.21203/rs.3.rs-1696532/v1","title":"SARS-CoV-2 Omicron BA.2.12.1, BA.4, and BA.5 subvariants evolved to extend antibody evasion","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Columbia College","funders":"National Institutes of Health; Regeneron Pharmaceuticals; Bill and Melinda Gates Foundation","keywords":"Evasion (ethics); Virology; Coronavirus disease 2019 (COVID-19); Antibody; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Chemistry; Biology; Medicine; Genetics; Infectious disease (medical specialty); Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006775684,0.0006881374,0.0004659236,0.0005238011,0.0003517322,0.001077278,0.0004764927,0.0009190483,0.007007769],"category_scores_gemma":[0.0007095142,0.0002555372,0.000657937,0.0004549072,0.0004269069,0.0003651142,0.0006197185,0.002290443,0.003106482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006626715,"about_ca_system_score_gemma":0.0005410817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001956421,"about_ca_topic_score_gemma":0.001699807,"domain_scores_codex":[0.9996271,0.00008767646,0.00003341861,0.00006344068,0.00008166773,0.0001067761],"domain_scores_gemma":[0.9996715,0.00006442856,0.00006422826,0.00006959648,0.00005625656,0.00007405201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001133947,0.0003762929,0.005547331,0.00009604501,0.0001417228,0.0008956222,0.0001304734,0.001403787,0.9631525,0.005544834,0.003819583,0.01775795],"study_design_scores_gemma":[0.0004079092,0.001743847,0.03518385,0.0001072423,0.0003398558,0.007570365,0.0003129984,0.01716898,0.781477,0.003191496,0.1523843,0.0001122024],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9699048,0.001716552,0.01345795,0.0008062526,0.0007759774,0.0001010756,0.002409605,0.0005188291,0.01030897],"genre_scores_gemma":[0.9803274,0.0003378949,0.005780413,0.000592986,0.00007850273,0.00004449236,0.003464524,0.0002876828,0.00908603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007007769,"threshold_uncertainty_score":0.02344334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1285461872379474,"score_gpt":0.4748514768493977,"score_spread":0.3463052896114503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}