{"id":"W4281992598","doi":"10.1016/j.heliyon.2022.e09629","title":"Bioinformatics analysis of adhesin-binding potential and ADME/Tox profile of anti-Helicobacter pylori peptides derived from wheat germ proteins","year":2022,"lang":"en","type":"article","venue":"Heliyon","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Bacterial adhesin; Peptide; Helicobacter pylori; Biochemistry; Allosteric regulation; ADME; Binding site; Chemistry; Docking (animal); Biology; Receptor; Escherichia coli; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001924659,0.0001625797,0.0006196953,0.0005047785,0.0001560556,0.00001613499,0.0001297553,0.00006183896,0.001538195],"category_scores_gemma":[0.00004564103,0.0001349746,0.0002303653,0.0006212713,0.0001406859,0.00009233054,0.0002642875,0.0002478028,0.00001122687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004253148,"about_ca_system_score_gemma":0.0001034965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004264408,"about_ca_topic_score_gemma":0.00002717665,"domain_scores_codex":[0.9982377,0.00007286848,0.0005167791,0.000218165,0.0006730349,0.0002814306],"domain_scores_gemma":[0.9991682,0.00008067384,0.0002172997,0.000260538,0.0001374199,0.0001359106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007604156,0.0002531332,0.1298156,0.001138895,0.001405107,0.00004253048,0.001811608,0.00004326967,0.8614944,0.00003591166,0.0001034971,0.003095645],"study_design_scores_gemma":[0.001687667,0.001111593,0.6425408,0.0003893757,0.001646073,0.00004098358,0.002322033,0.008474807,0.3397983,0.00001744905,0.001646895,0.0003240452],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967963,0.00100183,0.00006121532,0.0003448252,0.00006234855,0.0004782949,0.0007541803,0.00001922466,0.0004817989],"genre_scores_gemma":[0.995216,0.000682038,0.002691399,0.00007792511,0.00007332322,0.00003678801,0.0004707663,0.00001683463,0.0007349502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.521696,"threshold_uncertainty_score":0.9993745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02293663509396042,"score_gpt":0.2816865843587187,"score_spread":0.2587499492647583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}