{"id":"W4281993739","doi":"10.1093/bjs/znac176.003","title":"Intracellular Proprotein convertase subtilisin/kexin type 9: Recruitment and regulatory role in mitochondrial architecture and bioenergetic","year":2022,"lang":"en","type":"article","venue":"British journal of surgery","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Kexin; PCSK9; LDL receptor; Cell biology; Biology; Gene knockdown; Proprotein convertase; Internal medicine; Endocrinology; Medicine; Biochemistry; Lipoprotein; Cholesterol; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005205392,0.0001092263,0.0002749924,0.0001152815,0.00008388251,0.00003598478,0.00007675237,0.00007155075,0.00004400464],"category_scores_gemma":[0.0001295809,0.0001263324,0.00008034333,0.00008624691,0.00010093,0.000007458978,0.00009289462,0.0002503961,1.691593e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002369857,"about_ca_system_score_gemma":0.0002176459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001486306,"about_ca_topic_score_gemma":0.000101211,"domain_scores_codex":[0.998849,0.0001914495,0.000360581,0.0002124765,0.0001937222,0.0001927416],"domain_scores_gemma":[0.9995075,0.00002465387,0.0001754617,0.0001115216,0.00006284689,0.0001180577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001102728,0.000175256,0.005880368,0.00006171506,0.00008000411,0.00009225637,0.0001652739,0.0001313244,0.7687528,0.00001124076,0.0209243,0.2026227],"study_design_scores_gemma":[0.002224505,0.0003973783,0.02467532,0.0001812652,0.00005912516,0.006806756,0.0004497377,0.00001833851,0.06901867,0.0003575011,0.8953636,0.000447803],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9298776,0.06665201,0.00001549867,0.0001233419,0.003110165,0.0001840168,0.00002279805,0.000002460595,0.00001204908],"genre_scores_gemma":[0.9882205,0.006698139,0.0002859935,0.0001947601,0.00425258,0.00003104097,0.00003676087,0.00002801209,0.0002521985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8744393,"threshold_uncertainty_score":0.5151687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01519365133108877,"score_gpt":0.2213580917695946,"score_spread":0.2061644404385058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}