{"id":"W4281995453","doi":"10.3389/fnimg.2022.828767","title":"Cross-Sectional and Longitudinal Hippocampal Atrophy, Not Cortical Thinning, Occurs in Amyloid-Negative, p-Tau-Positive, Older Adults With Non-Amyloid Pathology and Mild Cognitive Impairment","year":2022,"lang":"en","type":"article","venue":"Frontiers in Neuroimaging","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Universität Rostock; Servier; Eisai; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Pfizer; Biogen; BioClinica; European Commission; Eli Lilly and Company; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Atrophy; Pittsburgh compound B; Hippocampal formation; Alzheimer's disease; Psychology; Pathology; Dementia; Internal medicine; Pathological; Alzheimer's Disease Neuroimaging Initiative; Amyloid (mycology); Cognitive decline; Medicine; Neuroscience; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001165543,0.0002509685,0.0002271538,0.0006446787,0.0002950311,0.0003220356,0.0002054446,0.0003285038,0.001441341],"category_scores_gemma":[0.002754691,0.000250466,0.0003195952,0.0004532416,0.0002607877,0.0004386253,0.0005378484,0.0001679793,0.0002110462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001221763,"about_ca_system_score_gemma":0.0002114863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002656921,"about_ca_topic_score_gemma":0.004975016,"domain_scores_codex":[0.9995673,0.00008346242,0.00005938052,0.0001782288,0.00008218914,0.00002936744],"domain_scores_gemma":[0.9989807,0.0001641566,0.0004980741,0.0001660447,0.0001286853,0.00006229998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002323221,0.00004194077,0.9886185,0.00002045159,0.000212068,0.0001194053,0.0001871274,0.0001695111,0.00188631,0.00003362722,0.0001020063,0.008376639],"study_design_scores_gemma":[0.00000273368,0.00004665771,0.9992129,0.000003022429,0.00002435789,0.0003014531,0.00003651837,0.0001320991,0.0001271158,0.00003663729,0.00007533797,0.000001174555],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987238,0.0002559972,0.0005269091,0.00001588205,0.000003632941,0.00001180994,0.0001650118,0.00001196008,0.0002849599],"genre_scores_gemma":[0.9991616,0.0000665898,0.0004139273,0.00001845867,0.000006287426,0.00001263704,0.0002068197,0.000002205856,0.0001113303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002656921,"threshold_uncertainty_score":0.006164014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01181482371689713,"score_gpt":0.2876292207579731,"score_spread":0.275814397041076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}