{"id":"W4281995453","doi":"10.3389/fnimg.2022.828767","title":"Cross-Sectional and Longitudinal Hippocampal Atrophy, Not Cortical Thinning, Occurs in Amyloid-Negative, p-Tau-Positive, Older Adults With Non-Amyloid Pathology and Mild Cognitive Impairment","year":2022,"lang":"en","type":"article","venue":"Frontiers in Neuroimaging","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Universität Rostock; Servier; Eisai; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Pfizer; Biogen; BioClinica; European Commission; Eli Lilly and Company; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Atrophy; Pittsburgh compound B; Hippocampal formation; Alzheimer's disease; Psychology; Pathology; Dementia; Internal medicine; Pathological; Alzheimer's Disease Neuroimaging Initiative; Amyloid (mycology); Cognitive decline; Medicine; Neuroscience; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005975156,0.0003405235,0.0004903148,0.0006400791,0.0003957559,0.0001009673,0.0001138587,0.00006245277,0.0001389235],"category_scores_gemma":[0.0001254969,0.0003045973,0.00006732332,0.0005122331,0.0008298746,0.0002597926,0.0003740069,0.001337396,0.000002180209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000242262,"about_ca_system_score_gemma":0.0001687661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001346408,"about_ca_topic_score_gemma":0.00001574876,"domain_scores_codex":[0.9966621,0.0003627277,0.0004431059,0.001033805,0.0007271731,0.0007711353],"domain_scores_gemma":[0.9991058,0.0002279703,0.0001175663,0.0001529731,0.0001568561,0.0002387947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007316808,0.0005592964,0.9831678,0.0001068285,0.0000721418,0.004034657,0.002008024,0.00001574025,0.0002517219,0.000006534955,0.0001681295,0.002292371],"study_design_scores_gemma":[0.01450248,0.002167659,0.9745954,0.0002425333,0.00006547406,0.001156142,0.003436335,0.003062112,0.0003949933,0.00005947201,0.0000110762,0.0003063847],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961833,0.0002612284,0.00091403,0.0004605003,0.000285409,0.001379477,0.00008599199,0.00003499224,0.0003950406],"genre_scores_gemma":[0.9971398,0.00007694888,0.001217474,0.0009377606,0.00005884137,0.0002839206,0.00006401206,0.00004513596,0.0001761096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008572403,"threshold_uncertainty_score":0.9999406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01181482371689713,"score_gpt":0.2876292207579731,"score_spread":0.275814397041076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}