{"id":"W4281996388","doi":"10.1093/neuonc/noac079.339","title":"LGG-25. The first-in-class ERK inhibitor ulixertinib (BVD-523) shows activity in MAPK-driven pediatric low-grade glioma models as single agent and in combination with MEK inhibitors or senolytics","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Berlin Institute of Health; Deutschen Konsortium für Translationale Krebsforschung; Freie Universität Berlin; McGill University Health Centre; Deutsches Krebsforschungszentrum; Humboldt-Universität zu Berlin; McGill University","keywords":"MEK inhibitor; In vivo; MAPK/ERK pathway; Trametinib; Cancer research; Pharmacology; Melanoma; Biology; Kinase; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001110341,0.000527199,0.0002996489,0.0003269815,0.0001024726,0.0002655775,0.0002502168,0.0003091007,0.001592094],"category_scores_gemma":[0.00005476301,0.0001104005,0.0002782434,0.0002140436,0.0001473467,0.0001601226,0.0001052494,0.0005722986,0.0005622633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004305562,"about_ca_system_score_gemma":0.000362034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001955879,"about_ca_topic_score_gemma":0.003946265,"domain_scores_codex":[0.9999272,0.00001217383,0.000004935189,0.00001359911,0.00001566981,0.00002655305],"domain_scores_gemma":[0.9999666,0.000003399167,0.000006882083,0.000003845005,0.000003212793,0.00001601299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001532261,0.0005414505,0.0004993632,0.0001663005,0.00003482883,0.0001171964,0.00001947879,0.000644894,0.9757358,0.0001206271,0.001446138,0.01914171],"study_design_scores_gemma":[0.0002522606,0.004969419,0.006130725,0.00001486666,0.00007644278,0.0005371089,0.0000242945,0.001070617,0.9788014,0.00004285999,0.008066614,0.0000134644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840609,0.005740099,0.00178186,0.0002492509,0.00005661358,0.0001084452,0.003028556,0.0006373072,0.004336918],"genre_scores_gemma":[0.9893854,0.002288937,0.001668687,0.00008407926,0.000006182773,0.00008475082,0.003459395,0.00003331403,0.002989346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001955879,"threshold_uncertainty_score":0.005326092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02696047180012988,"score_gpt":0.2703012109238171,"score_spread":0.2433407391236873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}