{"id":"W4282028660","doi":"10.1101/2022.06.10.495632","title":"Fundamental limits to progression of cellular life in frigid environments","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Canadian Institute for Advanced Research","keywords":"Yeast; Saccharomyces cerevisiae; Intracellular; Cell biology; Cell cycle; Biology; Reactive oxygen species; Budding yeast; Flux (metallurgy); Gene; Chemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005801251,0.0003291584,0.0005616749,0.0003938192,0.000509627,0.001244169,0.0008985329,0.001033662,0.001464763],"category_scores_gemma":[0.002610386,0.0003882585,0.000632443,0.000163937,0.001291888,0.0016155,0.0009929129,0.001068761,0.0002711321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001547361,"about_ca_system_score_gemma":0.0006062455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004016736,"about_ca_topic_score_gemma":0.00147661,"domain_scores_codex":[0.9997789,0.00003479194,0.000008942267,0.00008165553,0.00004031797,0.0000554379],"domain_scores_gemma":[0.9992076,0.0003105543,0.000212288,0.00007948716,0.00006687696,0.0001232886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0002905136,0.0001141081,0.009893497,0.0005281314,0.0001050633,0.0005342307,0.0005751019,0.3585638,0.1602669,0.4548965,0.002173253,0.01205902],"study_design_scores_gemma":[0.00004292868,0.0002553084,0.01513713,0.00015084,0.0000668741,0.0003853043,0.0003919486,0.7624993,0.02104176,0.1876018,0.01226039,0.0001663596],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8309267,0.006388997,0.1388258,0.002567811,0.0001798782,0.00003683338,0.0005198588,0.0002673876,0.0202867],"genre_scores_gemma":[0.9946063,0.001171629,0.002858534,0.00009976755,0.00002836266,0.00004278335,0.0000902251,0.00001902846,0.001083414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004016736,"threshold_uncertainty_score":0.01122695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01200853282957519,"score_gpt":0.2265024721017895,"score_spread":0.2144939392722143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}