{"id":"W4282033105","doi":"10.1056/nejmoa2203478","title":"Teclistamab in Relapsed or Refractory Multiple Myeloma","year":2022,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1114,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Institute of Cancer Research; Hotel Dieu Hospital","funders":"Janssen Research and Development; Winship Cancer Institute; School of Medicine, Stanford University; Cancer Center Amsterdam; Centro de Investigación Biomédica en Red de Cáncer; Eberhard Karls Universität Tübingen; National Cancer Institute; Institut d’Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona; Emory University; Universidad de Navarra; University College London; Memorial Sloan-Kettering Cancer Center; Perelman School of Medicine, University of Pennsylvania; Universitat de Barcelona; Vrije Universiteit Amsterdam; University of Pennsylvania; University of California, San Francisco; Comprehensive Cancer Center, City of Hope; National Institute for Health and Care Research; Leukemia and Lymphoma Society","keywords":"Multiple myeloma; Refractory (planetary science); Antibody; Cancer research; Antigen; Medicine; CD3; Immunology; Biology; CD8","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001272937,0.0001631977,0.0006014087,0.0005886448,0.00009855788,0.000005484233,0.0001798497,0.00004551248,0.002788548],"category_scores_gemma":[0.002021867,0.00009790993,0.00008570418,0.0004572367,0.00008033443,0.00006286137,0.00006521391,0.0009705739,0.000007861531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003599644,"about_ca_system_score_gemma":0.0006219462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003470146,"about_ca_topic_score_gemma":0.000185906,"domain_scores_codex":[0.9974689,0.0002425364,0.0006775157,0.0001706911,0.001107105,0.0003332046],"domain_scores_gemma":[0.9982544,0.000590271,0.0002795499,0.0002384383,0.0001283291,0.0005089954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.05035932,0.001246738,0.2275509,0.0001023307,0.0003583538,0.03001059,0.00280844,0.00009432174,0.01217089,0.00004021882,0.02961874,0.6456391],"study_design_scores_gemma":[0.3743024,0.01783746,0.2213432,0.0004940653,0.000164363,0.009463115,0.001579887,0.0004402173,0.0004157374,0.0002249147,0.3735503,0.0001843776],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856879,0.002185607,0.00004642284,0.00932956,0.0005216325,0.000327437,0.000007906572,0.00001641134,0.001877148],"genre_scores_gemma":[0.9934739,0.0002630776,0.000662741,0.0004992412,0.001457274,0.000008588028,0.00001791239,0.00002522557,0.003592008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6454548,"threshold_uncertainty_score":0.998123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04050119126847216,"score_gpt":0.323883615450082,"score_spread":0.2833824241816098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}