{"id":"W4282033105","doi":"10.1056/nejmoa2203478","title":"Teclistamab in Relapsed or Refractory Multiple Myeloma","year":2022,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1114,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Institute of Cancer Research; Hotel Dieu Hospital","funders":"Janssen Research and Development; Winship Cancer Institute; School of Medicine, Stanford University; Cancer Center Amsterdam; Centro de Investigación Biomédica en Red de Cáncer; Eberhard Karls Universität Tübingen; National Cancer Institute; Institut d’Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona; Emory University; Universidad de Navarra; University College London; Memorial Sloan-Kettering Cancer Center; Perelman School of Medicine, University of Pennsylvania; Universitat de Barcelona; Vrije Universiteit Amsterdam; University of Pennsylvania; University of California, San Francisco; Comprehensive Cancer Center, City of Hope; National Institute for Health and Care Research; Leukemia and Lymphoma Society","keywords":"Multiple myeloma; Refractory (planetary science); Antibody; Cancer research; Antigen; Medicine; CD3; Immunology; Biology; CD8","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005216761,0.0003260594,0.0007517164,0.0002719925,0.0002159989,0.0002467207,0.0002430845,0.0002794173,0.0008406009],"category_scores_gemma":[0.0004209543,0.00008822742,0.0003099109,0.0002770413,0.0001822176,0.0001787619,0.0001722712,0.0004677322,0.0002378293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004453702,"about_ca_system_score_gemma":0.0002903975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004627081,"about_ca_topic_score_gemma":0.001052591,"domain_scores_codex":[0.9998308,0.00005811462,0.00001670728,0.00002195495,0.00003547973,0.00003684224],"domain_scores_gemma":[0.9998253,0.00004263138,0.00005173759,0.00001062434,0.00001275047,0.00005697874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.08265459,0.006155193,0.1627071,0.002138512,0.001520404,0.00733201,0.000812541,0.006071168,0.1396529,0.0003705174,0.006504834,0.5840802],"study_design_scores_gemma":[0.05644342,0.232417,0.5480763,0.0005839604,0.002201228,0.03206566,0.0003966354,0.01180091,0.07212692,0.0007283706,0.04306267,0.00009692593],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914013,0.007429725,0.0001313921,0.0001368471,0.0000249666,0.00004991347,0.00007028182,0.00002876202,0.0007269342],"genre_scores_gemma":[0.9973781,0.001702011,0.0001794799,0.0001450769,0.00005004973,0.00002568597,0.0002217309,0.000003752964,0.0002941824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008406009,"threshold_uncertainty_score":0.003231347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04050119126847216,"score_gpt":0.323883615450082,"score_spread":0.2833824241816098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}