{"id":"W4282036173","doi":"10.1200/jco.2022.40.16_suppl.tps10062","title":"FIREFLY-1 (PNOC 026): A phase 2 study to evaluate the safety and efficacy of tovorafenib (DAY101) in pediatric patients with <i>RAF</i>-altered recurrent or progressive low-grade glioma or advanced solid tumors.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Centre hospitalier de l'Université Laval","funders":"","keywords":"Medicine; Oncology; Internal medicine; Adverse effect; Glioma; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008178962,0.001334639,0.001262276,0.0003201969,0.0002462467,0.0007074862,0.0008163728,0.001127448,0.002996939],"category_scores_gemma":[0.0004347043,0.0004317148,0.001023764,0.0003255041,0.0007151408,0.0006986691,0.0003731478,0.003239643,0.0007169867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001239313,"about_ca_system_score_gemma":0.002070154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001416015,"about_ca_topic_score_gemma":0.004724246,"domain_scores_codex":[0.9997587,0.00008301903,0.00001066607,0.00004953753,0.00003622823,0.00006194974],"domain_scores_gemma":[0.9995965,0.00004649645,0.00006712732,0.00003012873,0.00002327135,0.000236566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4118918,0.1063862,0.01501596,0.001980097,0.001733788,0.001836286,0.0008518661,0.004842401,0.2089482,0.001495365,0.01382701,0.231191],"study_design_scores_gemma":[0.426286,0.5172265,0.01464284,0.00007122309,0.0005800027,0.002157209,0.000110104,0.002698151,0.02533694,0.0003523424,0.01046685,0.00007181793],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918451,0.001895064,0.0008045103,0.0005361894,0.00009468619,0.001460441,0.001512745,0.0001722124,0.001679133],"genre_scores_gemma":[0.9824075,0.002361004,0.003606428,0.000994319,0.00008404882,0.002193948,0.004966323,0.00006367857,0.003322842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002996939,"threshold_uncertainty_score":0.0100258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07504121689368846,"score_gpt":0.4745597762813039,"score_spread":0.3995185593876154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}