{"id":"W4282048666","doi":"10.3390/v14061206","title":"D2I and F9Y Mutations in the NS1 Protein of Influenza A Virus Affect Viral Replication via Regulating Host Innate Immune Responses","year":2022,"lang":"en","type":"article","venue":"Viruses","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"State Key Laboratory of Veterinary Biotechnology; National Natural Science Foundation of China; University of Ottawa; National Key Research and Development Program of China; University of Wisconsin-Madison","keywords":"Biology; Virology; Virus; Viral replication; Influenza A virus; Innate immune system; Interferon; Mutant; Mutation; Immune system; Gene; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008940294,0.0003868806,0.0001919319,0.0001087039,0.00009957998,0.0001259861,0.0001377635,0.0002689732,0.0007359182],"category_scores_gemma":[0.00008318197,0.0001147316,0.0002999939,0.0000761082,0.0001767569,0.00009439346,0.0001097437,0.000270896,0.000220073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002351394,"about_ca_system_score_gemma":0.0001330216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006072781,"about_ca_topic_score_gemma":0.0006499051,"domain_scores_codex":[0.9999124,0.00002024826,0.0000106529,0.00002021947,0.00001914555,0.00001734785],"domain_scores_gemma":[0.9999466,0.00001064121,0.00001947044,0.000005674875,0.000004985833,0.00001261942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001209352,0.00002529131,0.0002912236,0.00001827824,0.000004832901,0.00006601469,0.000004930647,0.00006344249,0.9987954,0.00002871216,0.00001917597,0.0005616547],"study_design_scores_gemma":[0.00002924399,0.0005575242,0.01096311,0.000007580769,0.00003188781,0.000654045,0.00002776698,0.001619925,0.9844947,0.00004409012,0.001560602,0.000009428294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975763,0.0006468613,0.0009625887,0.00003858268,0.00001690962,0.00001612275,0.0002264931,0.00002485329,0.0004913485],"genre_scores_gemma":[0.9975095,0.0004193211,0.00102153,0.00003874884,0.000005068142,0.00001641624,0.0002617047,0.00001184467,0.0007158297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007359182,"threshold_uncertainty_score":0.002461851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08926341064327281,"score_gpt":0.3981942199604556,"score_spread":0.3089308093171828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}