{"id":"W4282052404","doi":"10.1101/2022.06.10.495573","title":"Human sperm TMEM95 binds eggs and facilitates membrane fusion","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"SLAC National Accelerator Laboratory; Biological and Environmental Research; Echo Foundation; Basic Energy Sciences; National Institute of Child Health and Human Development; Japan Society for the Promotion of Science; Office of Science; Buck Institute for Research on Aging; National Science Foundation; Damon Runyon Cancer Research Foundation; Virginia and D.K. Ludwig Fund for Cancer Research; U.S. Department of Energy; National Institutes of Health","keywords":"Sperm; Biology; Lipid bilayer fusion; Sterility; Hamster; Cell biology; Monoclonal antibody; Genetics; Molecular biology; Antibody; Membrane","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005710022,0.0005926172,0.0007538515,0.0004263274,0.0003787801,0.0001199477,0.0002207533,0.0004587711,0.001313297],"category_scores_gemma":[0.000292191,0.0005973889,0.0001987375,0.0004354792,0.0001694201,0.00009878709,0.0006668544,0.00112624,0.00006272788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003248743,"about_ca_system_score_gemma":0.0003272087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001550277,"about_ca_topic_score_gemma":0.00000221183,"domain_scores_codex":[0.997079,0.0001163815,0.0005245988,0.001170248,0.0006136231,0.0004961619],"domain_scores_gemma":[0.9977937,0.00006132897,0.0002521625,0.001212261,0.0002837519,0.0003967611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006799141,0.0002612991,0.04107231,0.0009940348,0.0002155843,0.0003001311,0.00003137971,0.00001771416,0.9562171,0.0003599293,0.000456995,0.000005527725],"study_design_scores_gemma":[0.002859692,0.0006371571,0.7935827,0.0007614063,0.0009524262,6.181249e-7,0.00003731048,0.0003884565,0.171949,0.000006811657,0.02744422,0.001380219],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946553,0.002005449,0.00005172296,0.0003827314,0.001129439,0.0009462886,0.0001758675,0.000549391,0.0001037823],"genre_scores_gemma":[0.9974118,0.0003513366,0.0009844564,0.0003093526,0.0005225097,0.0001883334,0.000004610469,0.0001357677,0.00009182269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7842681,"threshold_uncertainty_score":0.9996477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01773458804758227,"score_gpt":0.2478656868535956,"score_spread":0.2301310988060133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}