{"id":"W4282573439","doi":"10.1016/j.biopha.2022.113270","title":"Targeting cholesteryl ester accumulation in the heart improves cardiac insulin response","year":2022,"lang":"en","type":"article","venue":"Biomedicine & Pharmacotherapy","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fondo para la Investigación Científica y Tecnológica; European Regional Development Fund; Instituto de Salud Carlos III; Center for International Business Education and Research, University of Illinois at Urbana-Champaign; Secretaria de Ciencia y Tecnología - Universidad Nacional de Córdoba; Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas; Banco Bilbao Vizcaya Argentaria; Consejo Nacional de Investigaciones Científicas y Técnicas; Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares; Generalitat de Catalunya; Fundación BBVA; Fundació la Marató de TV3; Universitat de Barcelona; International Union of Biochemistry and Molecular Biology; Consejo Superior de Investigaciones Científicas; Universidad Nacional de Córdoba; European Foundation for the Study of Diabetes; Ministerio de Ciencia, Innovación y Universidades","keywords":"LRP1; GLUT4; Insulin receptor; Insulin; Internal medicine; Glucose transporter; Endocrinology; Biology; Chemistry; Insulin resistance; Cholesterol; Lipoprotein; LDL receptor; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001474358,0.0006067062,0.0004019994,0.0002140626,0.000140644,0.0002212069,0.0001898426,0.0003502325,0.001756393],"category_scores_gemma":[0.0001217473,0.000119672,0.0002465345,0.000102496,0.0002768198,0.0002330527,0.0002018606,0.0009177073,0.0003827397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001698008,"about_ca_system_score_gemma":0.0001696715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000169997,"about_ca_topic_score_gemma":0.0002301281,"domain_scores_codex":[0.9999053,0.00001323206,0.00001119199,0.00002169594,0.00001652449,0.00003191524],"domain_scores_gemma":[0.9998665,0.00001315781,0.00004069211,0.00001244408,0.00001588234,0.00005141964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005959215,0.0001212462,0.0001851031,0.00005536419,0.000007502961,0.00003249833,0.000005628109,0.00002116302,0.9972544,0.00002491408,0.00005413514,0.001642018],"study_design_scores_gemma":[0.0002252934,0.003380536,0.009932296,0.00001696159,0.00006540526,0.0004006916,0.00003260993,0.0005928176,0.9836038,0.00006673197,0.001675998,0.000006892717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956481,0.001078171,0.001859094,0.0001746625,0.00005593074,0.00003288826,0.0001490808,0.0001247384,0.000877378],"genre_scores_gemma":[0.9930111,0.001231559,0.002654328,0.0001906009,0.00004717613,0.00006969634,0.0003789623,0.00004554272,0.002371056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001756393,"threshold_uncertainty_score":0.005875766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03228562616174602,"score_gpt":0.3495473836895343,"score_spread":0.3172617575277883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}