{"id":"W4282579627","doi":"10.3390/medicines9060035","title":"Dichloroacetyl Amides of 3,5-Bis(benzylidene)-4-piperidones Displaying Greater Toxicity to Neoplasms than to Non-Malignant Cells","year":2022,"lang":"en","type":"article","venue":"Medicines","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Maunders Mcneil Foundation","keywords":"Cytotoxicity; Quantitative structure–activity relationship; Toxicity; Potency; Mitotic index; Chemistry; Cytotoxic T cell; Selectivity; Stereochemistry; Mode of action; Mechanism of action; In vitro; Mitosis; Structure–activity relationship; Biology; Pharmacology; Molecular biology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000152847,0.0003590182,0.0001915862,0.0001706365,0.0000819784,0.00009590623,0.0001675888,0.0001433483,0.001264123],"category_scores_gemma":[0.0001551962,0.0001012216,0.0001548245,0.0001258615,0.0001235502,0.0001400149,0.0001301615,0.0004390227,0.0003075976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001507542,"about_ca_system_score_gemma":0.0001720217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003597721,"about_ca_topic_score_gemma":0.0009898697,"domain_scores_codex":[0.9999206,0.00001952457,0.000008197325,0.0000158929,0.0000189413,0.00001683047],"domain_scores_gemma":[0.999899,0.00002460917,0.00003150174,0.000009913718,0.00001558062,0.00001936574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002749094,0.00005160549,0.0001301955,0.0001325806,0.000006103274,0.00008135666,0.00001875072,0.0004045094,0.9946254,0.00011419,0.00007662601,0.004083814],"study_design_scores_gemma":[0.00006275616,0.003486863,0.002267579,0.00001480152,0.00001985127,0.000351887,0.00002174304,0.0008280382,0.9884464,0.00004856742,0.004442886,0.000008709437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839827,0.003730743,0.005139061,0.0001266274,0.00004939679,0.0001245111,0.0005428838,0.0001070932,0.00619707],"genre_scores_gemma":[0.9909962,0.002194888,0.004072293,0.00006589368,0.00001531026,0.00005346797,0.0004505945,0.00001303342,0.002138282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001264123,"threshold_uncertainty_score":0.00422895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01676680422824888,"score_gpt":0.234245548872568,"score_spread":0.2174787446443192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}