{"id":"W4282582089","doi":"10.3390/pharmaceutics14061211","title":"Structural and Functional Validation of a Full-Thickness Self-Assembled Skin Equivalent for Disease Modeling","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Environmental Health Sciences; National Research Foundation of Korea","keywords":"Psoriasis; Basement membrane; Skin equivalent; In vitro; Chemistry; Parakeratosis; Human skin; Cell biology; Keratinocyte; Biomedical engineering; Biophysics; Dermatology; Biology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004892554,0.0003711318,0.0001853554,0.0002771449,0.0001046785,0.0002174337,0.0002984099,0.000456853,0.0007298368],"category_scores_gemma":[0.0004642834,0.0001584598,0.0003933488,0.0001124605,0.00019532,0.0002779626,0.0002076523,0.0003166174,0.0002352323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001414776,"about_ca_system_score_gemma":0.000116369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003592811,"about_ca_topic_score_gemma":0.0004259073,"domain_scores_codex":[0.9997515,0.00005849232,0.00001904309,0.00004163495,0.0001092125,0.00002015181],"domain_scores_gemma":[0.9997039,0.00006304403,0.00005665357,0.00005213008,0.00008664042,0.00003765364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003199155,0.00003540987,0.0001268641,0.00004313449,0.00001053785,0.00007886461,0.00001442741,0.001261413,0.9967189,0.00009449171,0.00003709818,0.001546804],"study_design_scores_gemma":[0.00001164369,0.0003808936,0.001555397,0.000007542174,0.00003657699,0.0002744125,0.00002217369,0.01206183,0.9833612,0.00004411969,0.002231316,0.00001291147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9434001,0.001111019,0.05283632,0.00009244006,0.00007820851,0.0001099529,0.0004302613,0.0002410761,0.001700604],"genre_scores_gemma":[0.9626117,0.0005965383,0.03471309,0.00006935805,0.000008211606,0.00006322191,0.0004626179,0.00004681776,0.00142832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007298368,"threshold_uncertainty_score":0.002587438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0699500105873922,"score_gpt":0.3137591159463936,"score_spread":0.2438091053590014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}