{"id":"W4282585028","doi":"10.1186/s41181-022-00165-0","title":"Synthesis of a 2-nitroimidazole derivative N-(4-[18F]fluorobenzyl)-2-(2-nitro-1H-imidazol-1-yl)-acetamide ([18 F]FBNA) as PET radiotracer for imaging tumor hypoxia","year":2022,"lang":"en","type":"article","venue":"EJNMMI Radiopharmacy and Chemistry","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Division of Graduate Education; Fundação de Amparo à Pesquisa do Estado de São Paulo; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Government of Canada","keywords":"Radiosynthesis; Tumor hypoxia; Acetamide; Chemistry; In vivo; Positron emission tomography; Hypoxia (environmental); High-performance liquid chromatography; Imaging agent; Nitroimidazole; Radiochemistry; Nuclear medicine; Oxygen; Medicine; Chromatography; Biology; Internal medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001573272,0.0003944438,0.0003563724,0.0001907577,0.0002068175,0.0001740537,0.000463744,0.0004703767,0.001090485],"category_scores_gemma":[0.0001535415,0.0001826383,0.0002520769,0.0002900762,0.0001623039,0.0002536894,0.0001704682,0.0003425099,0.0008030326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003430931,"about_ca_system_score_gemma":0.0005247031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00194856,"about_ca_topic_score_gemma":0.002632489,"domain_scores_codex":[0.9999121,0.00001291607,0.000006838966,0.00002303869,0.00002128728,0.00002370591],"domain_scores_gemma":[0.9999226,0.000009224688,0.00001893101,0.000009032896,0.00002205158,0.00001815643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003820953,0.00002675358,0.00006833174,0.0001185822,0.000005555927,0.0001764509,0.00002190246,0.0003170101,0.9957223,0.0002054425,0.00007799496,0.003221485],"study_design_scores_gemma":[0.00002753268,0.0003948857,0.0006628868,0.000009624125,0.00002354467,0.0004592434,0.00001213225,0.001204451,0.9897641,0.00004508812,0.007378235,0.000018345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8504146,0.01018706,0.1237824,0.0005546219,0.0002206779,0.0007454539,0.001666419,0.000882399,0.01154626],"genre_scores_gemma":[0.934766,0.003617483,0.05203861,0.0001076584,0.00003081916,0.0003147771,0.001138986,0.00005244561,0.007933145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00194856,"threshold_uncertainty_score":0.003874362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008257953942748763,"score_gpt":0.2553824058105807,"score_spread":0.2471244518678319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}