{"id":"W4282589544","doi":"10.1128/mbio.01239-22","title":"Phosphatidylinositol 3-Kinase (PI3K) Orchestrates Aspergillus fumigatus-Induced Eosinophil Activation Independently of Canonical Toll-Like Receptor (TLR)/C-Type-Lectin Receptor (CLR) Signaling","year":2022,"lang":"en","type":"article","venue":"mBio","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Deutsche Forschungsgemeinschaft","keywords":"Aspergillus fumigatus; Allergic bronchopulmonary aspergillosis; C-type lectin; Eosinophil; Immunology; Microbiology; Eosinophilia; Receptor; Signal transduction; Biology; Lectin; Chemistry; Cell biology; Immunoglobulin E; Antibody; Asthma; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003281527,0.0003359764,0.0005598377,0.0002127241,0.0004165039,0.00003404791,0.0002558068,0.0002122537,0.003148984],"category_scores_gemma":[0.0002399025,0.0003199829,0.0002304583,0.0007190309,0.0001085289,0.0001543909,0.0001589551,0.000679491,0.0000588811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004192053,"about_ca_system_score_gemma":0.001162013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000232965,"about_ca_topic_score_gemma":0.00001204064,"domain_scores_codex":[0.9971601,0.0002679286,0.0006524757,0.0005850387,0.0008631436,0.0004713088],"domain_scores_gemma":[0.9984326,0.0001645168,0.0003328912,0.0004563385,0.0002590068,0.000354657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002209915,0.001147992,0.01350591,0.0001678683,0.0001739347,0.00007315479,0.0005708208,0.0001490886,0.9669264,0.0001355967,0.0068217,0.008117604],"study_design_scores_gemma":[0.00368517,0.002990467,0.01278517,0.0002351746,0.0002161232,0.0000434213,0.002336287,0.0001977261,0.9357824,0.00003960561,0.04106703,0.0006214441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959497,0.0004932504,0.00001319031,0.0007798123,0.001332164,0.0006873208,0.00004555014,0.0001311021,0.0005679484],"genre_scores_gemma":[0.9967485,0.00001870834,0.0002397037,0.0006697918,0.0003501207,0.00007734723,0.0002486945,0.00006950921,0.001577634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03424533,"threshold_uncertainty_score":0.9999252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02353905636111751,"score_gpt":0.2703965309068634,"score_spread":0.2468574745457459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}