{"id":"W4282589544","doi":"10.1128/mbio.01239-22","title":"Phosphatidylinositol 3-Kinase (PI3K) Orchestrates Aspergillus fumigatus-Induced Eosinophil Activation Independently of Canonical Toll-Like Receptor (TLR)/C-Type-Lectin Receptor (CLR) Signaling","year":2022,"lang":"en","type":"article","venue":"mBio","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Deutsche Forschungsgemeinschaft","keywords":"Aspergillus fumigatus; Allergic bronchopulmonary aspergillosis; C-type lectin; Eosinophil; Immunology; Microbiology; Eosinophilia; Receptor; Signal transduction; Biology; Lectin; Chemistry; Cell biology; Immunoglobulin E; Antibody; Asthma; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008581461,0.0003340021,0.0001700923,0.0001735312,0.0002018983,0.0004455341,0.0001034821,0.0002273464,0.0008724815],"category_scores_gemma":[0.00007084482,0.00009086233,0.0002284688,0.0001292272,0.0001898437,0.0002253908,0.0003789647,0.000573451,0.0005327361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002667537,"about_ca_system_score_gemma":0.0002947845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006400626,"about_ca_topic_score_gemma":0.001251704,"domain_scores_codex":[0.9998878,0.00001410312,0.000007607843,0.00002123875,0.00001981656,0.00004938665],"domain_scores_gemma":[0.9999745,0.000002017364,0.000007560186,0.000002137322,0.000003835882,0.00001001961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005782846,0.00008943579,0.00114691,0.0001465346,0.00001524668,0.0002988939,0.00003136502,0.0002410436,0.9896479,0.0006101001,0.0004953113,0.006698901],"study_design_scores_gemma":[0.0002296782,0.0005384387,0.09389625,0.00009940198,0.0001488815,0.001247452,0.0004057028,0.01260832,0.8603461,0.001510622,0.02893981,0.00002927523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9677474,0.01437415,0.006740256,0.0008797655,0.0001860446,0.00009990736,0.001243037,0.0003224425,0.008406896],"genre_scores_gemma":[0.9933169,0.00288583,0.001160153,0.0001367603,0.00001609153,0.00003476775,0.0003441771,0.0000135268,0.002091796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008724815,"threshold_uncertainty_score":0.00291878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02353905636111751,"score_gpt":0.2703965309068634,"score_spread":0.2468574745457459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}