{"id":"W4282594980","doi":"10.24217/2531-0151.22v1s5.00021","title":"Monitoring One-carbon metabolism by mass spectrometry for early diagnosis of cirrhosis and HCC","year":2022,"lang":"en","type":"article","venue":"IBJ Plus","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Agencia Estatal de Investigación; Dirección General de Universidades e Investigación; European Regional Development Fund; Instituto de Salud Carlos III; Banco Santander; Centers for Disease Control and Prevention; Ministerio de Ciencia, Innovación y Universidades; Centro de Investigación Biomédica en Red de Cáncer; Centro de Biología Molecular Severo Ochoa; Consejería de Educación e Investigación; Ministerio de Asuntos Económicos y Transformación Digital, Gobierno de España; Ministerio de Educación, Cultura y Deporte; Consejo Superior de Investigaciones Científicas; Novo Nordisk Fonden; Ministerio de Ciencia y Tecnología; Universidad Autónoma de Madrid; Fundación Ramón Areces; Ministerio de Ciencia e Innovación; Novo Nordisk; Agencia Nacional de Investigación y Desarrollo; AXA Research Fund; European Social Fund; Fundació la Marató de TV3; Comunidad de Madrid","keywords":"Hepatocellular carcinoma; Cirrhosis; Liver cancer; Epigenetics; Medicine; Cancer; Cancer research; Steatosis; Viral hepatitis; Bioinformatics; Internal medicine; Oncology; Biology; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000869623,0.001016031,0.000449478,0.001309187,0.0002604438,0.0003648335,0.0004792878,0.0008925229,0.001113083],"category_scores_gemma":[0.0006552865,0.0002403136,0.0003624596,0.0006453112,0.0004361978,0.0003495332,0.0004021268,0.000674687,0.0007736381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003288735,"about_ca_system_score_gemma":0.0006408604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003679377,"about_ca_topic_score_gemma":0.0008346543,"domain_scores_codex":[0.9992365,0.0001382679,0.00003666095,0.0002218489,0.000300888,0.00006583305],"domain_scores_gemma":[0.9996765,0.00006258189,0.0001177476,0.0000234593,0.00007716395,0.00004257292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001964999,0.00006591289,0.003241983,0.0003465419,0.00004728838,0.0001001898,0.0000226493,0.0002653929,0.9791386,0.0002126976,0.0003485246,0.01601389],"study_design_scores_gemma":[0.00002604326,0.0005170481,0.009807048,0.00007232164,0.00007973808,0.0008018735,0.00004000827,0.006456124,0.9761352,0.0004000203,0.005622194,0.00004244047],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5646757,0.05743038,0.3602528,0.001282873,0.0007469106,0.0008165645,0.005119232,0.002571925,0.007103613],"genre_scores_gemma":[0.6865252,0.01418423,0.2913461,0.00107726,0.000230266,0.0006212962,0.002479933,0.0001605019,0.003375197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001309187,"threshold_uncertainty_score":0.004599035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01191271873173416,"score_gpt":0.2387637037969795,"score_spread":0.2268509850652453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}