{"id":"W4282595898","doi":"10.1165/rcmb.2021-0445oc","title":"Metabolic and Epigenetic Regulation of SMAD7 by STC1 Ameliorates Lung Fibrosis","year":2022,"lang":"en","type":"article","venue":"American Journal of Respiratory Cell and Molecular Biology","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Japan Society for the Promotion of Science","keywords":"Bleomycin; Pulmonary fibrosis; Oxidative stress; Fibrosis; Idiopathic pulmonary fibrosis; Fibroblast; Acetylation; Endoplasmic reticulum; Epigenetics; Chemistry; Glutathione; Pharmacology; Biology; Lung; Internal medicine; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001563569,0.0004753307,0.0005190856,0.0005520293,0.000211396,0.0002445896,0.0002168128,0.0003222874,0.001536502],"category_scores_gemma":[0.0001088024,0.0001657828,0.0004661568,0.0002217466,0.0003281926,0.0001699944,0.0002135302,0.0009742016,0.0002120208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002560621,"about_ca_system_score_gemma":0.000374438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008997588,"about_ca_topic_score_gemma":0.002155098,"domain_scores_codex":[0.9998485,0.00001989979,0.00001217254,0.00002489175,0.0000455708,0.00004904874],"domain_scores_gemma":[0.9998981,0.000008240162,0.00002909877,0.000007211104,0.00002159873,0.00003576415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001105646,0.0001758882,0.0007233441,0.0001889667,0.00003632949,0.00009319784,0.00002200005,0.0001525505,0.9922923,0.00009623304,0.000148357,0.004965207],"study_design_scores_gemma":[0.000182096,0.002058127,0.02396815,0.00003113144,0.0001611743,0.0003281217,0.0001234419,0.001824628,0.9661937,0.0001322648,0.004979599,0.00001763073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880559,0.006715383,0.002713176,0.0002687571,0.000121663,0.00005932551,0.0005034809,0.000175088,0.001387185],"genre_scores_gemma":[0.9929691,0.002680636,0.001373781,0.0001611363,0.00003385076,0.00006481251,0.0006688081,0.0000263097,0.002021487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001536502,"threshold_uncertainty_score":0.005140066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004278048146871244,"score_gpt":0.242211049525019,"score_spread":0.2379330013781477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}