{"id":"W4282821612","doi":"10.1016/j.isci.2022.104603","title":"Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca2+ release from the ER","year":2022,"lang":"en","type":"article","venue":"iScience","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Japan Science and Technology Agency; National Institutes of Health; Japan Diabetes Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; Astellas Foundation for Research on Metabolic Disorders; Gunma University; Mochida Memorial Foundation for Medical and Pharmaceutical Research; Yokohama City University; Japan IDDM network; Ministry of Education, Culture, Sports, Science and Technology; University of Alberta; Kobe University; Japan Agency for Medical Research and Development; Uehara Memorial Foundation; Naito Foundation","keywords":"Endoplasmic reticulum; Unfolded protein response; Mitochondrion; Internal medicine; Downregulation and upregulation; Endocrinology; Glycolysis; Pancreatic islets; Secretion; Insulin; Cell biology; Oxidative stress; Transgene; Genetically modified mouse; Biology; Islet; Chemistry; Biochemistry; Metabolism; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002460984,0.0001070409,0.0001388781,0.00003652402,0.0005207002,0.00005570839,0.00005859053,0.00002668331,0.0002064429],"category_scores_gemma":[0.0006821276,0.00007190467,0.00003133102,0.0002529477,0.0001293369,0.0001337355,0.00009352947,0.0002170384,0.000005059862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006206323,"about_ca_system_score_gemma":0.000106395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001030716,"about_ca_topic_score_gemma":0.000005029037,"domain_scores_codex":[0.998956,0.00006053128,0.0001556895,0.0003190707,0.0003236055,0.0001850645],"domain_scores_gemma":[0.9993477,0.0001787767,0.00007581232,0.0002048266,0.00003006207,0.0001628197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001330764,0.0001496187,0.04683185,0.00002375347,0.00003654182,0.00001771271,0.000851176,0.001019813,0.9243329,0.0000552766,0.007191242,0.01815939],"study_design_scores_gemma":[0.01706447,0.003982937,0.2611534,0.0004137508,0.0005109346,0.0001373845,0.006017979,0.6552683,0.03177537,0.003648286,0.01892362,0.001103539],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960412,0.001798983,0.0005106881,0.0008545439,0.0002019468,0.0003800193,0.00004610494,0.00004018523,0.0001263638],"genre_scores_gemma":[0.9982898,0.00001081745,0.0003684947,0.0007356002,0.0001543917,0.00005098831,0.00002233077,0.000008980972,0.0003586075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8925575,"threshold_uncertainty_score":0.4004858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01200113172860062,"score_gpt":0.2431169727462359,"score_spread":0.2311158410176353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}