{"id":"W4282823071","doi":"10.3390/cells11121915","title":"Challenges in Cell Fate Acquisition to Scid-Repopulating Activity from Hemogenic Endothelium of hiPSCs Derived from AML Patients Using Forced Transcription Factor Expression","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Induced pluripotent stem cell; Biology; Haematopoiesis; RUNX1; Stem cell; Cell biology; Progenitor cell; Cancer research; Transplantation; ETS transcription factor family; Transcription factor; Immunology; Regenerative medicine; Embryonic stem cell; Medicine; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000632945,0.0001802482,0.0002003133,0.0001906391,0.0001882826,0.0005340977,0.0002168955,0.0002565858,0.001079402],"category_scores_gemma":[0.000247092,0.0001193999,0.0002714425,0.0001007899,0.0002296249,0.0001712532,0.0003153112,0.0008547808,0.0004263822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001630525,"about_ca_system_score_gemma":0.0002331916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002489027,"about_ca_topic_score_gemma":0.000520302,"domain_scores_codex":[0.9996069,0.00008941296,0.00005416849,0.00005972717,0.0001461343,0.00004364202],"domain_scores_gemma":[0.9997708,0.00006822669,0.0000466141,0.00005208681,0.0000326634,0.00002959214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006664476,0.00004606918,0.00111404,0.00006153748,0.00001194744,0.0001428732,0.0000859166,0.000186646,0.9914533,0.0005401637,0.0001144126,0.006176443],"study_design_scores_gemma":[0.00001620846,0.0003494862,0.007873888,0.00002624683,0.00004407472,0.001801543,0.0001436351,0.001721617,0.978684,0.0001737036,0.009158731,0.000006822999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809306,0.001510077,0.01338539,0.000349372,0.0000402444,0.0001135737,0.0003012852,0.0001179229,0.003251577],"genre_scores_gemma":[0.9899329,0.001053201,0.005940939,0.0001866044,0.0000140515,0.00009592323,0.0005372986,0.00002858149,0.002210607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001079402,"threshold_uncertainty_score":0.003610969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04874352192487785,"score_gpt":0.2747389363504365,"score_spread":0.2259954144255586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}