{"id":"W4282823071","doi":"10.3390/cells11121915","title":"Challenges in Cell Fate Acquisition to Scid-Repopulating Activity from Hemogenic Endothelium of hiPSCs Derived from AML Patients Using Forced Transcription Factor Expression","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Induced pluripotent stem cell; Biology; Haematopoiesis; RUNX1; Stem cell; Cell biology; Progenitor cell; Cancer research; Transplantation; ETS transcription factor family; Transcription factor; Immunology; Regenerative medicine; Embryonic stem cell; Medicine; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00013122,0.0001687034,0.0002120969,0.00009998322,0.0001090764,0.0000128378,0.0002247168,0.0001118591,0.0001016416],"category_scores_gemma":[0.00001460408,0.0001863554,0.0001001772,0.00008603733,0.00001997534,0.00001324622,0.0002660547,0.0001482121,0.000003693392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001064364,"about_ca_system_score_gemma":0.00003759337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000407873,"about_ca_topic_score_gemma":0.00004694747,"domain_scores_codex":[0.9982315,0.0003150129,0.0002769303,0.0005354961,0.0003514586,0.0002895804],"domain_scores_gemma":[0.9993193,0.00002927267,0.0001605444,0.000351429,0.00005171141,0.00008779676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003408778,0.0001846971,0.002645791,0.00003170013,0.00001273532,0.000002429757,0.0005120461,0.002051802,0.9923824,8.364048e-8,0.000006490327,0.001828953],"study_design_scores_gemma":[0.001039633,0.0001793656,0.0217044,0.00003222478,0.000008993228,2.188246e-7,0.0002107922,0.0009001528,0.9756651,0.00001681546,0.00006575813,0.0001765321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974114,0.0004419262,0.0009616146,0.00001860878,0.0002052051,0.0004592988,0.0004228452,0.000009046973,0.00007008363],"genre_scores_gemma":[0.9985588,0.00009706301,0.0008362944,0.00002453181,0.0000586517,0.00003112068,0.0003315339,0.00003181502,0.0000302312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01905861,"threshold_uncertainty_score":0.7599354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04874352192487785,"score_gpt":0.2747389363504365,"score_spread":0.2259954144255586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}